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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Improving engraftment potential of hMSCs after encapsulation in collagen microsphere: an in vitro and in vivostudy

Wong, Mei-yi., 王美兒. January 2012 (has links)
Stem cell-based therapies are promising in regenerative medicine. However, the success of cell therapy is greatly limited by the low engraftment rate to the target tissues. The present study demonstrated that human mesenchymal stem cells (hMSCs) were subjected to a self selection process via microencapsulation in collagen barrier when they were induced to migrate out from this barrier. While retaining the immuophenotype and self renewal capacity, the selected hMSCs showed a significantly better in vitro migratory response of than those cultured in traditional monolayer. The migratory response could be controlled by varying the fabrication parameters of the collagen barrier, including initial collagen concentration and cells seeding density. Affinity to adhere on endothelial cells layer is another engraftment related property. Significant difference was observed between these selected hMSCs and hMSCs in monolayer culture. In order to investigate the engraftment potential of the selected hMSCs, an animal model was performed. The selected hMSCs were transplanted intravenously into NOD/SCID mice under partial hepatectomy. Presence of human cells in the residual liver was determined by the presence of human HLA-ABC using flow cytometry after 48 hours, 1 week and 1 month. Engraftment of the selected hMSCs was significantly higher than that of monolayer cultured hMSCs in time point of 1 month. It demonstrated that the selected hMSCs favor the engraftment to the injured liver. Further investigation is required to determine the fate of the engrafted hMSCs in order to truly confirm their therapeutic potential. The current work demonstrated that collagen-hMSCs microsphere could act as a barrier to select hMSCs with enhanced in vitro migratory response and in vivo engraftment properties. These findings may contribute towards the development of better stem cell therapies. / published_or_final_version / Mechanical Engineering / Master / Master of Philosophy
12

Effects of pituitary transplantation in cockerels

Koelling, Norman Eugene, 1932- January 1969 (has links)
No description available.
13

Human fetal tissue transplantation an Orthodox Christian ethical evaluation /

Chudik, John D. January 1994 (has links)
Thesis (M. Div.)--St. Vladimir's Orthodox Theological Seminary, Crestwood, NY, 1994. / Includes bibliographical references (leaves 37-41).
14

Migration and other characteristics of collagen microencapsulated hMSCs a comparison with hMSCs in traditional 2D culture /

Wong, Hoi-ling. January 2008 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2009. / Includes bibliographical references (leaves 69-83) Also available in print.
15

Transplantation antibodies

Perper, Robert J., January 1967 (has links)
Thesis--University of California. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
16

The ethics of fetal tissue research and transplant

Waln, Donna L. January 1998 (has links)
Thesis (M. A.)--Trinity Evangelical Divinity School, Deerfield, Ill., 1998. / Abstract. Includes bibliographical references (leaves 125-134).
17

Transplantation antibodies

Perper, Robert J., January 1967 (has links)
Thesis--University of California. / Includes bibliographical references.
18

Studies of the graft host interaction in the mouse

McRae, James. January 1961 (has links)
Thesis (Ph. D. in Medical Physics)--University of California, Berkeley, Jan. 1961. / Includes bibliographical references (leaves 72-82).
19

Medical benefit and the human lottery an egalitarian approach to patient selection /

Waring, Duff William Ramus, January 2004 (has links)
Based on Ph.D. thesis. / Includes bibliographical references (p. 201-216) and index.
20

Glucoregulation during an acute bout of exercise in post pancreatic-kidney transplant recipients

Adamson, Carisa Harris. January 2002 (has links)
Thesis (M.S.)--San Francisco State University, 2002. / Includes bibliographical references (leaves 29-54).

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