京都大学 / 新制・課程博士 / 博士(医学) / 甲第23367号 / 医博第4736号 / 新制||医||1051(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 森田 智視, 教授 川上 浩司, 教授 佐藤 俊哉 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

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By means of a Monte Carlo study, this paper investigates the relative performance of Listwise Deletion, the EM-algorithm and the default algorithm in the MICE-package for R (PMM) in estimating regression coefficients under a left truncated covariate with missing values. The intention is to investigate whether the three frequently used missing data techniques are robust against left truncation when missing values are MCAR or MAR. The results suggest that no technique is superior overall in all combinations of factors studied. The EM-algorithm is unaffected by left truncation under MCAR but negatively affected by strong left truncation under MAR. Compared to the default MICE-algorithm, the performance of EM is more stable across distributions and combinations of sample size and missing rate. The default MICE-algorithm is improved by left truncation but is sensitive to missingness pattern and missing rate. Compared to Listwise Deletion, the EM-algorithm is less robust against left truncation when missing values are MAR. However, the decline in performance of the EM-algorithm is not large enough for the algorithm to be completely outperformed by Listwise Deletion, especially not when the missing rate is moderate. Listwise Deletion might be robust against left truncation but is inefficient.

Submitted by Haroudo Xavier Filho (haroudo.xavierfo@ufpe.br) on 2016-04-05T14:28:43Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) dissertacao_Raphaela(CD).pdf: 1067677 bytes, checksum: 6d371901336a7515911aeffd9ee38c74 (MD5) / Made available in DSpace on 2016-04-05T14:28:43Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) dissertacao_Raphaela(CD).pdf: 1067677 bytes, checksum: 6d371901336a7515911aeffd9ee38c74 (MD5) Previous issue date: 2015-07-31 / CAPES / Este trabalho analisa propriedades da família de distribuições de probabilidade Composta N e propõe a sub-família Composta Poisson-Truncada como um meio de compor distribuições de probabilidade. Suas propriedades foram estudadas e uma nova distribuição foi investigada: a distribuição Composta Poisson-Truncada Normal. Esta distribuição possui três parâmetros e tem uma flexibilidade para modelar dados multimodais. Demonstramos que sua densidade é dada por uma mistura infinita de densidades normais em que os pesos são dados pela função de massa de probabilidade da Poisson-Truncada. Dentre as propriedades exploradas desta distribuição estão a função característica e expressões para o cálculo dos momentos. Foram analisados três métodos de estimação para os parâmetros da distribuição Composta Poisson-Truncada Normal, sendo eles, o método dos momentos, o da função característica empírica (FCE) e o método de máxima verossimilhança (MV) via algoritmo EM. Simulações comparando estes três métodos foram realizadas e, por fim, para ilustrar o potencial da distribuição proposta, resultados numéricos com modelagem de dados reais são apresentados. / This work analyzes properties of the Compound N family of probability distributions and proposes the sub-family Compound Poisson-Truncated as a means of composing probability distributions. Its properties were studied and a new distribution was investigated: the Compound Poisson-Truncated Normal distribution. This distribution has three parameters and has the flexibility to model multimodal data. We demonstrated that its density is given by an infinite mixture of normal densities where in the weights are given by the Poisson-Truncated probability mass function. Among the explored properties of this distribution are the characteristic function end expressions for the calculation of moments. Three estimation methods were analyzed for the parameters of the Compound Poisson-Truncated Normal distribution, namely, the method of moments, the empirical characteristic function (ECF) and the method of maximum likelihood (ML) by EM algorithm. Simulations comparing these three methods were performed and, finally, to illustrate the potential of the proposed distribution numerical results with real data modeling are presented.