This study examines ultrastructural changes occurring in seven- and fourteen-day populations of Trypanosorfa lewisi when 60 mg sodium salicylate is administered to the host. These changes were related to the host-immune response. Seven-day trypanosomes showed approximately 10 posterior volutin granules. Seven-day trypanosomes whose host had received salicylate exhibited. 30 to 40 volutin granules, and their posterior tip exhibited volutin granules in high numbers sometimes excluding other cellular elements. Fourteen-day trypanosones showed fewer volutin granules than seven-day, salicylate-treated ones. Salicylate treatment caused no additional ultrastructural alterations. Thus the volutin granules are not linked to the reproduction inhibiting antibody (ablast in) but may be involved in the formation of the trypanocidal antibodies.

The purpose of this study was to examine the ultrastructure of both young (dividing form) and adult (stationary form) of Trypanosoma lewisi. Changes observed between the two forms of the organism were related directly to data obtained from previous comparative biochemical studies conducted on these forms of Trypanosoma lewisi.

Thesis (M.S.)--University of Wisconsin--Madison, 1964. / eContent provider-neutral record in process. Description based on print version record. Bibliography: l. 68-72.

The immunological responses in hosts infected with Trypanosoma lewisi were examined during the course of infection and after recovery. Peak antibody levels coincided with the time of parasite elimination, but remained significantly elevated for over one year after the end of the infection The antigen repertoire recognized by antibodies demonstrated that some were revealed only by sera taken during the infection, and other antigens were revealed for the first time only by post-recovery sera. Immunomodulatory protective and suppressive factors were demonstrated in the plasma of irradiated, infected rats. These factors were identified as parasite-derived exoantigens which are shed in vivo and in vitro; exoantigens are complexes of proteins, lipids and polysaccharides and are membrane-surface coat associated, as shown by phase-partitioning and surface-labeling studies. The suppressive activity of the exoantigens was dose-dependent, probably mediated by a suppressor substance(s) produced by macrophages that subsequently inhibits production of interleukin 2 by T helper cells.

Thesis (Ph. D.)--University of Wisconsin, 1955. / Typescript (carbon copy). eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 124-125).

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