In Ghana, spatial patterns of TB vary for different regions and variations may occur within the same region. This study examines TB distribution in the Greater Accra Region of Ghana using Geographic Information Systems (GIS). Behavioral, cultural and economic variables associated with TB morbidity are examined. From January 1998 to June 1999, data obtained from the Ghana Ministry of Health revealed that, men had a higher TB rate than women, TB was common among the age groups 20-29 and 30-39, and the average TB rate of 67.7 per 100, 000 population in the Greater Accra Region was higher than the national average (58.6 per 100,000 population). Using the human ecology model, this study attempts to explain the spatial distribution of the disease.