In this study, I examined the Supreme Court's agenda from 1801 to 1993 to determine the composition and dynamics of the issues that have dominated the business of the Court. Specifically, I set out to test empirically Robert G. McCloskey's (now standard) characterization of the Supreme Court's history, which sees it as dominated by nationalism/federalism issues before the Civil War, by economic issues just after the War through the 1930s, and by civil rights and liberties since the 1930s. The question that drove my investigation was "Is McCloskey's interpretation, which appears to be based on the great cases of Supreme Court history, an accurate description of the agenda represented in the Supreme Court's total body of reported decisions?" To test McCloskey's historical theses I employed concepts adapted from Richard Pacelle's (1991) important work on the agenda of post-Roosevelt Court and used the methods of classical historical analysis and of interrupted time-series analysis. Data for my research came from existing datasets and from my own collection (I coded the manifest content of thousands of Supreme Court's decisions from 1887 back to 1801). The most important finding from my analyses is that McCloskey not withstanding, the pre-Civil War Supreme Court's agenda was clearly dominated by economic issues of various sorts, not by nationalism/federalism as previously believed. Another key finding is that partisanship had a pronounced impact on the Court's attention to this category of issueseven in the periods when the Supreme Court had very little control of its docket. These results suggest that Supreme Court scholars should reassess or rethink their previous notion of the Court's pre-Civil War agendathe now well-established view that nation-state issues dominated the business of the Court in its formative yearsand the idea (often expressed implicitly) that the Court's mandatory jurisdiction suppressed attitudinal factors on the Court in the earlier eras.