The US-Israel relations were based on the US political and strategic interests in the Middle East. The beginning of relations resulted from the Israel&rsquo / s strategic importance for United States to contain the Soviet sponsored-communism and its location to easy access oil reserves. The bilateral relation, especially after the 1967 Arab-Israeli War, was transformed into a special relation. However, following the election of George Bush as President of the US, the US-Israeli relations rose and reached its peak in the 8-year period of his Administration. For that reason, this thesis aims at analyzing the role of the Jewish lobbies, in the context of the US-Israeli relations from 1948 to 2008, particular focusing on the Bush Administration period. This study tries to answer the question of to what extent does the Jewish lobby influence foreign policy or to what extent does the Jewish lobby has the relative strength of influence than other ethnic groups or lobbies in the US foreign policy-making process is another aim of this study. This thesis argues that the Jewish lobby has been highly affectively to influence the US foreign policy-making process. In addition, it also argues that the US foreign policy is based on importance of presidency and therefore it is impossible to explain American foreign policy without highlighting the personality and belief system of Presidents.