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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
191

Impacto do reprocessamento de dialisadores de alto fluxo e alta eficiência sobre o transporte de solutos em sessões de hemodiafiltração online curta diária / Reprocessing high-flux, high-efficiency polysulfone dialyzers on solutes removal in short daily online hemodiafiltration

Natália Corrêa Vieira de Melo 05 December 2013 (has links)
Introdução: Não há estudos que avaliem o impacto da reutilização do dialisador na remoção de solutos em sessões de hemodiafiltração online curta diária (HDF-OL-D). Objetivo: Avaliar o impacto do reuso do dialisador na dose do tratamento, na cinética de beta2-microglobulina e na extração de solutos em sessões de HDF-OL-D e comparar com sessões de hemodiálise curta diária de alto fluxo (HD-D). Métodos: Foram incluídos 14 pacientes do programa de HD-D. Foram coletadas amostras de sangue pré, no meio e pós-diálise e amostras do dialisato no 1º, 7º e 13º usos do dialisador em sessões de HD-D e de HDF-OL-D. Resultados: A massa total extraída (MTDQ) e a depuração (KDQ) diretamente quantificada dos solutos pequenos (ureia, fósforo, creatinina e ácido úrico), bem como a dose de diálise ofertada, foram semelhantes quando o 1º, 7º e 13º usos do dialisador em sessões de HD-D foram comparados, respectivamente, ao 1º, 7º e 13º usos em sessões de HDF-OL-D. A MTDQ e a KDQ dos solutos pequenos e a dose de diálise foram semelhantes entre os usos do dialisador tanto em sessões de HD-D e quanto em sessões de HDF-OL-D. A MTDQ, a KDQ e o Kt/V diretamente quantificado (Kt/VDQ) de beta2-microglobulina foram maiores em sessões de HDF-OL-D do que nos respectivos usos do dialisador em sessões de HD-D. Não houve diferença quanto à cinética de beta2-microglobulina, avaliada pela MTDQ, KDQ ou Kt/VDQ, entre o 1º, 7º e 13º usos do dialisador em sessões de HD-D nem em sessões de HDF-OL-D. Na HDF-OL-D, a perda intradialítica de albumina foi significativamente diferente entre os usos do dialisador (p < 0,001), estando reduzida no 7º e 13º usos, quando comparados ao 1º uso do dialisador. Não houve correlação entre o volume de enchimento do dialisador e a MTDQ e a KDQ de moléculas pequenas em nenhum dos métodos dialíticos estudados. Em sessões de HDF-OL-D, foi observada uma correlação fraca entre o volume de enchimento do dialisador e a KDQ de beta2-microglobulina, não percebida com a MTDQ ou o Kt/VDQ de beta2-microglobulina. Conclusão: O reprocessamento de dialisadores de alto fluxo e alta eficiência não resulta em comprometimento da dose do tratamento, da cinética de beta2-microglobulina nem da extração de solutos em sessões de HDF-OL-D. A extração de beta2-microglobulina foi maior em sessões de HDF-OL-D do que em sessões de HD-D, sem diferenças significativas na remoção dos demais solutos. O reprocessamento do filtro, em sessões de HDF-OL-D, resultou numa redução significativa da perda intradialítica de albumina. Não parece haver influência do volume de enchimento do filtro na extração de solutos em nenhum dos métodos de diálise estudados / Introduction: There no studies evaluating the impact of dialyzer reutilization on solute removal in daily online hemodiafiltration (D-OL-HDF) sessions. Objectives: Our aim was to evaluate the impact of dialyzer reuse on solute extraction, beta2-microglobulin kinetics and dialysis dose in D-OL-HDF and compare to those in high-flux short daily hemodialysis (D-HD). Methods: 14 patients undergoing a D-HD program were included. Pre, middle and post-dialysis blood samples and effluent dialysate were collected in the 1st, 7th and 13th dialyzer uses in D-HD sessions and in D-OL-HDF sessions. Results: Directly quantified small solute (urea, phosphorus, creatinine and uric acid) total mass removal (TMDQ) and clearance (KDQ), as well as dialysis dosis, were similar when the 1st, 7th and 13th dialyzer D-HD uses were compared to the 1st, 7th and 13th D-OL-HDF uses. TMDQ and KDQ of small solutes and dialysis dose were similar among dialyzer uses in D-HD sessions and also in D-OL-HDF sessions. beta2-microglobulin TMDQ, KDQ and directly quantified Kt/V (Kt/VDQ) were statistically higher in D-OL-HDF dialyzer uses than in the respective D-HD uses. There was no difference in beta2-microglobulin kinetics, evaluated by TMDQ, KDQ or Kt/VDQ, among 1st, 7th and 13th uses in D-OL-HDF sessions or in D-HD sessions. In D-OL-HDF, albumin loss was significantly different among studied dialyzer uses (p < 0.001), being reduced in the 7th and 13th dialyzer uses, when compared to the first use. There was no correlation between dialyzer priming volume and small molecules TMDQ, KDQ in neither analyzed dialytic method. In D-OL-HDF sessions, it was observed a week correlation between dialyzer priming volume and beta2-microglobulin KDQ, not observed with beta2-microglobulin MTDQ or Kt/VDQ. Conclusion: High flux, high efficiency dialyzer reprocessing did not did result in a reduction of the offered dialysis dose, beta2-microglobulin kinetics or solute extraction in D-OL-HDF. beta2-microglobulin removal was greater in D-OL-HDF than in D-HD sessions, without difference in other solutes extraction. There was a significant reduction in intradialytic albumin loss with dialyzer reprocessing in D-OL-HDF sessions. Dialyzer priming volume does not appear to influence solute removal in neither analyzed dialytic method
192

Inoculation with Azospirillum brasilense associated with silicon applied to correct soil acidity and nitrogen rates in corn and wheat crops /

Galindo, Fernando Shintate. January 2020 (has links)
Orientador: Marcelo Carvalho Minhoto Teixeira Filho / Resumo: Alternative management practices are needed to minimize the need for chemical fertilizer use in non-leguminous cropping systems. The use of biological agents which can fix atmospheric nitrogen and promote plant growth has shown potential as an option to improve soil nutrient availability to grass crops. In recent years, studies investigating the effects of silicon (Si) have increased substantially, especially in grain crops. This increased interest in Si is likely due to the beneficial effects of Si application on plant resistance to abiotic and biotic stresses, reflecting on greater plant development. This research was developed to investigate if inoculation of corn and wheat with Azospirillum brasilense associated with Si can enhance nitrogen use efficiency (NUE) and improve plant nutrition and yield, leading to a greater economic profit. The study was set up in a Rhodic Haplustox under no-till system, located in Selvíria, state of Mato Grosso do Sul, Brazil. The field trial took place during the 2015/16 (November-March), 2016 (April-September), 2016/17 (November-March) and 2017 April-September) seasons, with corn and wheat crops in sucession (spring/summer and winter seasons for corn and wheat, respectively). Treatments were tested in a randomized completely block design with four replicates, arranged in a full factorial design 5 × 2 × 2 and included: i) five N application rates, as urea source, applied in side-dressing (0, 50, 100, 150 and 200 kg ha-1); ii) two liming sou... (Resumo completo, clicar acesso eletrônico abaixo) / Doutor

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