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Defining the protective role of cathelicidin on ulcerative colitis in miceTai, Kin-ki, Emily., 戴健琦. January 2007 (has links)
published_or_final_version / Pharmacology / Doctoral / Doctor of Philosophy
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Impact of macronutrient restriction and probiotic supplementation on protein synthesis and growth in a piglet model of dextran sulphate-induced colitisFraser, Keely Gabrielle. January 2006 (has links)
A dextran sulphate (DS) model of ulcerative colitis was used to examine the effects of macronutrient restriction with (MR+PRO) and without (MR) probiotic supplementation (VSL#3RTM) on protein metabolism and growth. MR and MR+PRO decreased weight and chest circumference gain, but had no effect on linear growth of piglets. MR decreased the protein fractional synthesis rate (FSR) of liver, masseter, longissimus dorsi, colon, as well as plasma albumin, measured by stable isotope tracer L-[ring-2H 5]phenylalanine. MR+PRO increased the FSR of hepatic proteins by greater than 70% and increased both the FSR and absolute synthesis rate (ASR) of the total plasma protein pool, albumin and fibrinogen. Over 11 days, MR+PRO piglets showed a smaller decrease in plasma total protein concentrations than WN piglets, and maintained higher albumin levels than either WN or MR piglets. These findings highlight the importance of adequate nutrition during gastrointestinal inflammation and show that when food intake is decreased, probiotics stimulate liver protein synthesis and increase the acute phase protein response, similar to the well-nourished state.
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Colonic morphological changes in rat model of TNBS-induced colitis after oral feeding of Bifidobacterium infantis, a probioticAlsahly, Musaad Bedah 14 December 2013 (has links)
Access to abstract permanently restricted to Ball State community only. / Access to thesis permanently restricted to Ball State community only. / Department of Physiology and Health Science
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Impact of macronutrient restriction and probiotic supplementation on protein synthesis and growth in a piglet model of dextran sulphate-induced colitisFraser, Keely Gabrielle. January 2006 (has links)
No description available.
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Study of the protective effects of polysaccharides from Angelica sinensis on ulcerative colitis in ratsWong, Kai-chung., 黃啟宗. January 2006 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
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The regulatory effects of Bifidobacterium infantis on the secretomotor activity of the enteric nervous system after oral feeding in animal model of TNBS colitisFurman, David T. 05 August 2011 (has links)
Bifidobacterium infantis (BI) and other probiotics are non-pathogenic living organisms that have recently gained attention for their possible therapeutic implications on the health of the digestive tract. The mechanisms by which probiotics exert their effects are largely unknown. This study explored the protective and regulatory effect of oral BI on the enteric nervous system (ENS) in the TNBS-induced colitis rats. Electrical field stimulation and chemical stimulation by serotonin (5-HT) were used to elicit changes in the short-circuit current (Isc) response of the colonic rat tissue. BI-fed colitis rats expressed trends of higher secretomotor activity and revealed signs of decreased macroscopic inflammatory damage when compared to sham-fed colitis rats, suggesting a protective and preventative role of oral BI. These findings may provide additional insights for understanding the prophylactic and therapeutic value of specific probiotics in intestinal inflammatory disorders, offering the possibility of a noninvasive alternative to toxic and immune-compromising drugs. / Access to thesis permanently restricted to Ball State community only / Department of Physiology and Health Science
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