Human society in the 21st century, population pressures brought about by globalization, the unequal distribution of environmental hazards, and a variety of public issues become not by the traditional government alone; has been, non-governmental organization (NGO) in the global the role in a variety of topics, are the key to lead the relationship between state and society in the discussions of civil society and international governance, the NGO has become increasingly critical, even in order to achieve democracy, with human rights, a indicators. After 1978, the Communist Party power succession by designated has passed three generations. 2012, mainland China's power struggle with severe economic test can reveal the opportunity for Chinese mainland state machine transition is not yet known; But no matter how, recalling the moment in 2008, it was a in the north hosting the Olympic Games to the international community show the elements of national power, surprisingly actually first in the Southern earthquake relief shown. The Corporatism defined the mode of interdependence between the NGOs and the government is built on the concept of exchange, of which the most important connotation is the country's laws, institutions and regulations; the organization can not just exist with its own objectives and efficiency relevant professional space must comply with the external specification, which includes the cultural system, moral values. National units the role of classification screening system for the development of mainland China NGO, the NGO in the process of development, whether it can have more than "Legitimacy" is even more important.

Complex medication regimens have major implications on patient therapy. When we consider that these regimen therapies can also be further convoluted by co-morbidity, it is then seen as an essential opportunity to research possible solutions to alleviate such complications. Globally identified conditions such as the Human Immuno-deficiency Virus (HIV) and Tuberculosis (TB) are known to have such complications within their respective regimens. In many cases, the regimental therapies themselves are overbearing with high pill burdens having to be taken in segregated manners throughout the day. Within a standard TB regimen, isoniazid and rifampicin are seen to have a deleterious drug-drug interaction in which the bioavailability is compromised through formation of an insoluble complex. Despite this interaction, the 2 active drugs must be taken concurrently for successful TB therapy. No true solution exists as fixed dose combinations of isoniazid and rifampicin (Rifinah®) are still in production despite the detrimental interaction that impedes successful bioavailability. The once daily multi-unit drug delivery system (ODMUS) has the benefits of superseding the described problems and aiding in therapeutic outcomes. Preliminary studies utilized preliminary testing to ascertain the science surrounding the 2 components of the ODMUS, the memblet and the multiparticulate components. pH-sensitive polymers (Eudragit® L100-55 and E 100) were of critical importance to the success of the system and were individually manipulated for each component to produce a novel memblet and multiparticulate system through a unique salting out approach. Primary studies focused on drug release testing and drug entrapment for the multiparticulate component. Testing of the memblet system addressed dissolution and thermal analysis. Utilizing this data, a series of process variables were used to achieve an optimized formulation through a Box- Behnken statistical design. Optimized formulations used response testing to establish the optimal characteristics of both components. Multiparticulates achieved controlled release for 12 hours with an enhanced 71% drug entrapment efficiency. Memblet release profiles were confirmed over 2 hours with a maximal Tg of 56°C. Molecular modeling corroborated release understanding for both components. Surface area and porosity analysis, surface morphology, fourier transform infrared spectroscopy as well as thermal, rheological and mechanical analysis were additional tests undertaken on the optimized formulations. In vivo analysis was the final testing to verify validity of the ODMUS components and utilized a pig model for the investigation. UPLC blood analysis revealed increase blood levels of INH (CmaxINH= 0.0138ng/mL) and RIF (CmaxRIF= 0.052ng/mL) in relation to conventional dosage forms validating segregated site-specific release and increased bioavailability. Ideally, a segregated means of drug delivery throughout the gastrointestinal tract was achieved such that an enhanced bioavailability, a more controlled release and a simplified medication regimen was produced. This study aimed to achieve said goals through novel technique analysis, innovation and globally approved science to critically assess the success of the ODMUS as a potential means to reduce the complexities of medication regimen therapy.

James A. Mackay was a decorated World War II veteran, who returned to Georgia in 1945, determined to make a difference in the segregated world of Georgia politics. He was a staunch opponent of Georgia’s county unit system that entrenched political power in rural counties. From 1950 through 1964 he was a state house member who fought to keep Georgia public schools open in the face of political opposition to desegregation. Elected to Congress in 1964, he was one of two deep-South congressmen who voted in favor of the 1965 Voting Rights Act. In 1967 he co-founded the Georgia Conservancy. For the next 25 years he was Georgia’s leading environmentalist. This thesis explores Mackay’s life from 1919-1950 and the significance of his parents, his experiences at Emory University, World War II, his legal challenge to the county unit system, and his role in writing Who Runs Georgia?

ABSTRACT James A. Mackay was a decorated World War II veteran, who returned to Georgia in 1945, determined to make a difference in the segregated world of Georgia politics. He was a staunch opponent of Georgia’s county unit system that entrenched political power in rural counties. From 1950 through 1964 he was a state house member who fought to keep Georgia public schools open in the face of political opposition to desegregation. Elected to Congress in 1964, he was one of two deep-South congressmen who voted in favor of the 1965 Voting Rights Act. In 1967 he co-founded the Georgia Conservancy. For the next 25 years he was Georgia’s leading environmentalist. This thesis explores Mackay’s life from 1919-1950 and the significance of his parents, his experiences at Emory University, World War II, his legal challenge to the county unit system, and his role in writing Who Runs Georgia?

Approved for public release; distribution is unlimited. / MBA Professional Report / This project provides an analysis of the Army's acquisition of the Land Warrior (LW) Soldier System. Its objectives are to document the history of the LW and provide an overview of the program to establish the components of both it development and deployment and its associated business and management characteristics. The product is a document that provides an analysis of the actions taken and the obstacles encountered and how the materiel developers, warfighters, user representatives and lawmakers dealt with them. The LW was approved in 1993. The requirement was to provide improvements for dismounted soldiers in the five specific capabity caategories of lethality, command and control, mobility, survivability and sustainment. For a period lasting approximately 15 years, the LW has evolved. Despite this evolution, the Army in FY 2007 terminated it in FY 2007. Regardless, it has laid the foundation for follow-on soldier system initiatives. The LW was unsuccessfu initially due to the misalignment of three interrelated and supporting components; 1) technical immaturity, 2) poor user acceptance, and 3) lack of senior leadership support. Successes that are more recent can be attributed to: 1)soldier-driven design, 2) improved technical maturity, and 3) proven employment of the system in combat by warfighters.