This study explores for gender-based differences in the determinants of employee acceptance of organizational change among employees at the University of Botswana. Utilising a sample of 360 respondents drawn from academic and managerial staff the study sought to test for male-female differences in the acceptance of change, explore for male-female differences in the major factors that affect acceptance of change, and to test for male-female differences in the effects of the major determinants of acceptance of organizational change. Self-administered questionnaires were used to collect the data required for the study. The bulk of the data were analysed using SPSS statistical package with the t-test and regression (beta) coefficients ~s the key test statistics. The study showed that the overall acceptance of organizational change among employees was moderate with male and female employees being equally likely to accept the changes taking place at the workplace. However, the sexes differed significantly in the levels of 10 of the 20 determinants of acceptance of change analysed with women, relative to men, being substantially lower in promotional opportunity, work overload, job-skill match, participative management, trust in leadership, receptivity, and in job satisfaction and higher in routinization, enthusiasm, and desire to leave. Results for regression analyses showed that eight (8) of 19 substantive variables were significant determinants of acceptance of change for all employees. However, separate regression models for men and women revealed that 11 of 19 substantive factors were significant determinants of acceptance of change for males compared to two factors for females. Although the level of acceptance of change does not differ by the sex, male and female employees have different orientations to the change processes taking place in the organization and warrant separate treatment by management if organizational change is to be successful and yield the desired results. / Thesis (M.Admin (Public admin)) North-West University, Mafikeng Campus, 2003