Crashes categorized as running red light or left turning are most likely to occur at signalized intersections and resulted in substantial severe injuries and property damages. This dissertation mainly focused on these two types of vehicle crashes and the research methodology involved several perspectives. To examine the overall characteristics of red-light running and left-turning crashes, firstly, this study applied 1999-2001 Florida traffic crash data to investigate the accident propensity of three aspects of risk factors related to traffic environments, driver characteristics, and vehicle types. A quasi-induced exposure concept and statistical techniques including classification tree model and multiple logistic regression were used to perform this analysis. Secondly, the UCF driving simulator was applied to test the effect of a proposed new pavement marking countermeasure which purpose is to reduce the red-light running rate at signalized intersections. The simulation experiment results showed that the total red-light running rate with marking is significantly lower than that without marking. Moreover, deceleration rate of stopping drivers with marking for the higher speed limit are significantly less than those without marking. These findings are encouraging and suggesting that the pavement marking may result in safety enhancement as far as right-angle and rear-end traffic crashes at signalized intersections. Thirdly, geometric models to compute sight distances of unprotected left-turns were developed for different signalized intersection configurations including a straight approach leading to a straight one, a straight approach leading to a curved one, and a curved approach leading to a curved one. The models and related analyses can be used to layout intersection design or evaluate the sight distance problem of an existing intersection configuration to ensure safe left-turn maneuvers by drivers.