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digitalisering@umu

digitalisering@umu.se

Ketamine, widely used as an anesthetic since the 1970s, recently gained U.S. Food and Drug Administration (FDA) approval for treatment-resistant depression as a nasal spray. The use of off-label IV ketamine for pain relief, depression, and suicidal ideation has yielded promising results, but the consequences of long-term ketamine treatment have not received adequate attention. The dramatic, irreversible changes to the bladder seen in ketamine abusers and animal models should raise red flags, but the urgent need for effective depression medications prompted expedited FDA approval. Therefore, it is of the upmost importance to understand the deleterious effect of ketamine on the bladder and potentially other organ systems before a severely vulnerable patient population is exposed to dosages of ketamine that have yet to be examined for their long-term safety. Through an evaluation of current research, a two-pronged mechanism of ketamine-induced cystitis, involving nerve hypertrophy and incomplete apoptosis, was elucidated and may serve as a valuable guide for clinical care decisions, further research, and development of efficacious treatments

<p>2022-03-23</p>

Purpose: The relationship between testicular cancer and working as a firefighter has been a relatively brushed off scope of concentration until recent years and recent developments in hopes of presenting new protocols and better guidelines to screen for testicular cancer in this occupation. The purpose of this study was to perform a scoping review to present the current data concerning testicular cancer and its association to the occupation of firefighters. Methods: PubMed as a data base was used and articles concerning firefighters and testicular cancer were found and screened for eligibility with respect to the kind of study and the data it entailed. Data was reported in this study and discussed. Results: It was found that testicular cancer has the highest or second highest incidence and mortality rate among all the cancers that firefighters suffer from at the P < 0.001 significance. Among the second highest were also skin, pleural, and thyroid cancer. Conclusion: While testicular cancer is highly treatable due to its high survival rate, it has a strong and alarming prominent presence in the firefighter occupation. The results should be interpreted with caution due to the limitations of the studies evaluated, however in all studies, testicular cancer had a far more significant incidence and mortality risk than the other cancers firefighters were evaluated for.

No description available.

Thesis (M.D.) -- University of Adelaide, Dept. of Surgery, 2000. / Includes bibliographical references.

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Includes bibliographical references. / 1 v. : / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / A thesis based on collective clinical, basic research material and publications in endoscopic paediatric surgical procedures. Discusses the application of adult percutaneous renal surgical techniques for managing renal calculi disease in children, and modifications to this technique. Describes the introduction to laparoscopic surgery and the author's contribution to this technique. Also includes publications on paediatric urology. / Thesis (M.D.)--University of Adelaide, Dept. of Surgery, 2000