Indiana University-Purdue University Indianapolis (IUPUI) / This thesis contains four interrelated research areas. Before presenting the four research areas, this thesis presents literature review on Software-Defined Networking (SDN), a network architecture that allows network operator to manage the network using high level abstractions. This thesis presents taxonomy for classifying SDN research. In research first area, this thesis presents Video over Software-Defined Networking (VSDN), a network architecture that selects feasible paths using the network-wide view. This thesis describes the VSDN protocol which is used for requesting service from the network. This thesis presents the results of implementing VSDN prototype and evaluates behavior of VSDN. Requesting service from the network requires developer to provide three input parameters to application programmable interface. The message complexity of VSDN is linear. In research second area, this thesis presents Explicit Routing in Software-Defined Networking (ERSDN), a routing scheme that selects transit routers at the edge of network. This thesis presents the design and implementation of ERSDN. This thesis evaluates the effect of ERSDN on the scalability of controller by measuring the control plane network events-packets. ERSDN reduces the network events in the control plane by 430%. In research third area, this thesis presents Reliable Video over Software-Defined Networking (RVSDN) which builds upon previous work of Video over Software-Defined Networking (VSDN) to address the issue of finding most reliable path. This thesis presents the design and implementation of RVSDN. This thesis presents the experience of integrating RVSDN into ns-3, a network simulator which research community uses to simulate and model computer networks. This thesis presents RVSDN results and analyzes the results. RVSDN services 31 times more requests than VSDN and Multiprotocol Label Switching (MPLS) explicit routing when the reliability constraint is 0.995 or greater. In research fourth area, this thesis presents Multi-Domain Video over Software-Defined Networking (MDVSDN), a network architecture that selects end-to-end network path or path for real-time interactive video applications across independent network domains. This thesis describes the architectural elements of MDVSDN. This thesis presents the results of implementing a prototype of MDVSDN and evaluates the behavior of MDVSDN. The message complexity of MDVSDN is linear. The contribution of this thesis lays the foundation for developing a network architecture that improves the performance of real-time interactive video applications by selecting feasible end-to-end multi-domain path among multiple paths using bandwidth, delay, jitter, and reliability.