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Mechanical optimization of vascular bypass graftsFelden, Luc. January 2005 (has links) (PDF)
Thesis (M. S.)--Mechanical Engineering, Georgia Institute of Technology, 2005. / David N. Ku, Committee Chair ; Alexander Rachev, Committee Co-Chair ; Elliot L. Chaikof, Committee Member. Includes bibliographical references.
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Perfusion bioreactor for tissue-engineered blood vesselsWilliams, Chrysanthi, January 2003 (has links) (PDF)
Thesis (Ph. D.)--School of Biomedical Engineering, Georgia Institute of Technology, 2004. Directed by Timothy M. Wick. / Vita. Includes bibliographical references (leaves 182-195).
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Material property testing of a collagen/smooth muscle cell gel for the development of a tissue engineered vascular graftGreer, Linda S. 05 1900 (has links)
No description available.
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Matrix metalloproteinases and the engineering of a vascular constructJohnson, Chad E. 08 1900 (has links)
No description available.
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Importance of local haemodynamics in the performance of the Miller cuff anastomosisCarpenter, Trevor Keith January 1998 (has links)
No description available.
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A theoretical approach to synthetic vascular graft design : surface micro-topography optimization for promoting the retention of endothelial cellsMarasco, Christina C. January 2007 (has links)
Thesis (M. S. in Biomedical Engineering)--Vanderbilt University, May 2007. / Title from title screen. Includes bibliographical references.
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Artificial arteries and bioreactors /Daly, Chris D. January 2005 (has links) (PDF)
Thesis (M.Phil.) - University of Queensland, 2005. / Includes bibliography.
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Characterization of PVA hydrogels with regards to vascular graft developmentElshazly, Tarek Hassan. January 2004 (has links) (PDF)
Thesis (M.S.)--Mechanical Engineering, Georgia Institute of Technology, 2004. / Dr. David Ku, Committee Chair ; Dr. Raymond Vito, Committee Member ; Dr. Alexander Rachev, Committee Member. Includes bibliographical references (leaves 103-106).
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Development and Utilization of a Tissue Engineered Blood Vessel Mimic to Assess the Neointimal Response to Intravascular StentsCardinal, Kristen O'Halloran January 2007 (has links)
The use of intravascular stents to restore blood flow through restricted vessels in patients with coronary artery disease has become the preferred method for treating a variety of lesion locations and pathologies. As new stent configurations and coatings are developed, a great need exists for high-throughput preclinical evaluation techniques that can interface human tissue with three-dimensional devices. Thus, the goals of this dissertation research were 1) to develop an in vitro blood vessel mimic composed of human cells for preclinical evaluation of intravascular devices, and 2) to utilize the mimic to assess neointimal responses to implanted stents.Experiments in support of these goals were broken into four specific aims. The first aim was to develop an in vitro human blood vessel mimic based on techniques for creating tissue engineered vascular grafts. The second aim was to determine the feasibility of utilizing this vessel mimic for bare metal stent evaluation. The third aim was to use the in vitro vessel to evaluate the cellular response to protein-coated stents. The fourth aim was to take advantage of the ability to control the in vitro vessel environment in order to evaluate the effect of shear rate on the neointimal response to implanted stents.Human blood vessel mimics were created by sodding fat-derived microvascular endothelial cells onto expanded polytetrafluoroethylene grafts and cultivating the vessels in bioreactor systems. This resulted in the development of a luminal lining of endothelial cells with sub-endothelial smooth muscle and mesenchymal cells. Deployment and assessment of bare metal stents within blood vessel mimics supported the feasibility of using the model for stent evaluation, and demonstrated that cell coverage of the device surface could be observed and measured. Protein-modified stents were created by submerging devices in enriched medium, and following implantation in the blood vessel mimic exhibited increased cell coverage and increased tissue thickness as compared with bare metal stents. Finally, an increase in shear rate lead to decreased neointimal coverage of implanted bare metal and modified stents. Overall, this dissertation demonstrates that in vitro human blood vessel mimics can be created and utilized for preclinical device evaluation.
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The role of proliferation and migration in endothelial cell monolayer formation on a tissue engineered blood vessel wall modelKladakis, Stephanie M. 12 1900 (has links)
No description available.
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