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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Static Vascular Modeling of Diabetes Progression

Skattenborg, Andrea 01 June 2023 (has links) (PDF)
Cardiovascular disease is the leading cause of mortality in diabetic patients, and diabetes is one of the main causes of cardiovascular disease. Risk factors for cardiovascular disease result in structural and functional changes in the vascular wall. Arterial stiffness is a prominent structural change observed in the arterial wall that can be measured in clinical settings. The purpose of this thesis was to create a static model of the changes in arterial stiffness seen in diabetes. Elastic tubes with varying wall thicknesses were used to create artificial arteries for this purpose. Compliance (inverse of stiffness) of the arteries was determined using a pressurevolume model and a mathematical model. The compliance curves generated using the pressurevolume model exhibited trends predicted by the mathematical model. These trends were comparable to arterial stiffness changes seen in diabetes. Compliance obtained from pressurevolume measurements of elastic tubes with varying wall thickness can therefore be used to model the general trends of arterial stiffness in diabetes.

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