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Epigenetic Basis for Heterogeneity in VCAM-1 Gene Expression Patterns in Cytokine Activated Vascular EndotheliumJamal, Alisha Noorin 01 January 2011 (has links)
Vascular cell adhesion molecule-1 (VCAM-1) is a cytokine-activated protein present on endothelial cells (ECs). Our laboratory has provided evidence that DNA methylation, a mark associated with gene silencing, is fundamental for regulating VCAM-1 expression. First, we showed that RNA polymerase II, preferentially associates with VCAM-1 hypomethylated alleles. This finding was confirmed using fluorescence-activated cell sorting (FACS) to sort populations of cytokine-activated ECs with high vs. low cell surface VCAM-1 expression. We found that ECs with high VCAM-1 expression were hypomethylated at the promoter. We then went on to show that populations of cells generated from single ECs exhibit differential VCAM-1 methylation from one another, and from the original founder population. Intriguingly, our data shows that VCAM-1 mRNA levels differ between the clones, and correlate with the observed differences in DNA methylation. Taken together, this data provides exciting evidence that DNA methylation is important in the regulation of VCAM-1 gene expression.
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Role of shear stress in angiopoietin-2-dependent neovascularization:Tressel, Sarah Lynne. January 2008 (has links)
Thesis (Ph. D.)--Biomedical Engineering, Georgia Institute of Technology, 2008. / Committee Chair: Jo, Hanjoong; Committee Member: McIntire, Larry; Committee Member: Nie, Shuming; Committee Member: Taylor, Robert; Committee Member: Weyand, Cornelia.
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Relationship between psychological status and vascular function in subjects with and without cardiovascular diseasesChen, Hua, January 2008 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2008. / Includes bibliographical references (leaf 109-129) Also available in print.
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Modulation of endothelium-dependent contractions by chronic inhibition of nitric oxide synthase in the rat aortaQu, Chen, January 2008 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2008. / Includes bibliographical references (leaves 96-112) Also available in print.
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Cellular mechanisms of effects of sphingosine 1-phosphate on vascular endothelial barrierXu, Mei, January 2008 (has links)
Thesis (Ph. D.)--West Virginia University, 2008. / Title from document title page. Document formatted into pages; contains ix, 109 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
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Relationship between psychological status and vascular function in subjects with and without cardiovascular diseases /Chen, Hua, January 2008 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2008. / Includes bibliographical references (leaf 109-129) Also available online.
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Regulation of inflammtory [sic] activation in endothelial cells by PIN1Liu, Tongzheng, January 2009 (has links)
Thesis (Ph. D.)--Ohio State University, 2009. / Title from first page of PDF file. Includes bibliographical references (p. 202-241).
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Endothelium-dependent hyperpolarization and relaxation of vascular smooth muscleZygmunt, Peter. January 1995 (has links)
Thesis (doctoral)--Lund University, 1995. / Added t.p. with thesis statement inserted.
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Endothelium-dependent hyperpolarization and relaxation of vascular smooth muscleZygmunt, Peter. January 1995 (has links)
Thesis (doctoral)--Lund University, 1995. / Added t.p. with thesis statement inserted.
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Interaction of vascular structure and function with myocardial ischaemia and survival /Fathi, Robert B. January 2004 (has links) (PDF)
Thesis (Ph.D.) - University of Queensland, 2003. / Includes bibliography.
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