The St. Lawrence Platform is located along the northern shoreline of Lake Ontario, currently in an intra-cratonic setting exposing relatively flat-lying middle Ordovician sedimentary strata. The purpose of this study is to gain insight on recent brittle deformation events that have deformed the bedrock. Based on structural field observations, broadly trending E-W extensional joints are the youngest stress recorded in the bedrock. These joints are partially filled and sealed with calcite mineralization and were strategically sampled to gain insight on the source and timing of fluid flow. Trace element geochemistry and stable isotope (δ18O and δ13C) analysis on calcite mineralization indicate that their compositions are analogous to the host rock, thus, fluids originate from connate fluids that were released from pore space during deformation. In addition, U-Pb geochronology via LA-ICP-MS methods yield a model age of 101 ± 6 Ma (MSWD: 2.3). The date of calcite crystallization is contemporaneous with the establishment of North America’s modern compressive stress field, and is linked to a Cretaceous tectonic plate reorganization event that was global in scale. This study demonstrates that calcite veins can serve as a tool to date brittle deformation in limestone, which could have direct applications in hydrocarbon exploration, paleohydrology, and the consideration for locating sites to host deep geological repositories.

Thesis (M. S.)--Bioengineering, Georgia Institute of Technology, 2010. / Committee Chair: Ku, David; Committee Member: Gleason, Rudolph; Committee Member: Milner, Ross. Part of the SMARTech Electronic Thesis and Dissertation Collection.

No description available.

Venous leg ulceration (VLU) affects roughly 0.6 percent of the western population, with the management of this condition in Australia alone accounting for between AUD$554 and AUD$655 million in health care expenditure every year. Apart from these financial implications, VLU is also associated with a number of adverse psychosocial effects, including depression, anxiety, social isolation, impaired mobility and reduced working capacity. Whilst compression therapy remains the primary treatment of choice for VLU, discomfort, poor compliance and potentially serious complications demand that a more convenient, safer and efficacious treatment of venous ulceration be developed. A herbal extract proposed to advance venous ulcer healing through its venotonic, anti-inflammatory, anti-oedema, anti-enzymatic and anti-exudative properties is Horsechestnut Seed Extract (HCSE). / Thesis (PhDNursing)--University of South Australia, 2005.

Atherosclerosis 'is a key pathological process underlying the development and progression of three major diseases of the vascular system- coronary artery disease, cerebro-vascular and peripheral vascular disease. Chronic vascular wall inflammation is considered as a principal cause in the initiation and progression of atherosclerosis. Intimal thickening that develops in arteries and veins as an adaptive response to an injury has many similarities with atherosclerosis, but at the same time represents a unique pathological entity. This Thesis explores the utility of applying a novel DNAzyme based approach that targets "master-regulator" transcription factors c-jun and Egr-1 to in vivo and in vitro models of acute inflammation and intimal thickening. Studies included in this Thesis reveal that transcription factor c-jun plays a, key regulatory role in controlling leucocyte movement during an acute inflammation induced by IL-1 f3 through regulation of the expression of adhesion molecules ICAM, VCAM-1, E-selectin and VE-cadherin. Similarly, by applying ED5, a DNAzyme that targets transcription factor Egr-1 to the rat model of mesenteric microcirculation I demonstrate that Egr-1 controls leucocyte movement during an acute inflammation as evidenced by almost complete inhibition of leucocyte flux, adhesion and extravasation by ED5. The rabbit model of bypass grafting shows that Dz13 (a DNAzyme targeting transcription factor c-jun) significantly reduces intimal thickening in bypassed vein grafts of chow-fed animals at 28 days in vivo and in culture-grown human saphenous veins in vitro. Taken together these findings suggest that a DNAzyme based approach of targeting transcription factor c-jun has the potential to be used as a modulator of the acute inflammatory response and of intimal thickening formation. Further work needs to be done before this technology is ready for clinical use in humans.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1969. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Orientador: Celso Antonio Rodrigues / Banca: Marcos Jun Watanabe / Banca: Delphim da Graça Macoris / Banca: Luis Cláudio Lopes Correia da Silva / Banca: Caio Biasi Mauro / Resumo: Em bovinos a venografia retrógrada podal é pouco descrita, quando comparada com a espécie equina. O objetivo deste estudo foi descrever a técnica de venografia retrógrada podal em vacas, comparando os acessos da veia digital dorsal comum III com a digital comum II ou IV, nos membros torácicos e pélvicos mediante a administração de dois diferentes volumes de contraste. Foram utilizados 53 membros torácicos e pélvicos de 14 vacas, contidas em decúbito lateral no tronco com o torniquete de borracha posicionado a 5 cm do paradígito. Administrou-se 10 mL do diatrizoato de meglumine em 24 membros (grupo 1), sendo 13 na veia digital dorsal comum III pelo acesso 1 (A1) e 11 na digital II ou IV no acesso 2 (A2). No grupo 2, administrou-se 20 mL em 29 membros, sendo 15 pelo A1 e 19 no A2. Após a administração do contraste, as radiografias foram repetidas a cada 20 segundos até 120 segundos, na projeção dorso palmar/plantar 0°. O grau de preenchimento vascular foi maior no grupo 2, independente do acesso venoso, do membro ou momento. Não houve diferença significativa no grau de radiopacidade das imagens radiográficas quando comparado o acesso venoso, momento e membro de ambos os grupos. Conclui-se que a administração de 20 ml de contraste apresentou melhor preenchimento e radiopacidade, não havendo diferença entre 20 e 120 segundos após a administração do contraste na qualidade radiográfica independente do acesso venoso / Abstract: In cattle the foot retrograde venography is rarely described, compared with the equine species. The aim of this study was to describe the technique of retrograde venography foot in cows, comparing the approaches of the dorsal common digital vein III with the digital commons II or IV, thoracic and pelvic by administering two different volumes of contrast members. Were used fifty tree fore and hindlimbs of 14 cows, contained in the lateral position on the trunk with rubber tourniquet placed at 5 cm from paradígito were used. Was administered 10 mL of diatrizoate meglumine 24 members (group 1), 13 dorsal common digital vein III for access 1 (A1) and 11 digital II or IV access 2 (A2). In group 2 was administered 20 mL 29 members, 15 by 19 in A1 and A2. After contrast administration, the radiographs were repeated every 20 seconds until 120 seconds, back projection on the palmar/plantar 0°. The degree of vascular filling was greater in group 2, independent of venous access, member or moment. There was no significant difference in the degree of radiopacity of radiographic images when compared to the venous access, time and a member of both groups. We conclude that administration of 20 ml of contrast showed better filling and radiopacity, with no difference between 20 and 120 seconds after contrast administration in independent radiographic quality venous access / Doutor

From introduction: Vein-type mineralization, particularly gold, copper, tin and tungsten has provided a source of metal to man for over 2000 years. These deposits are usually small but in some cases are of very high grade. Prior to 1940 veins were extremely important sources of metals because of their relatively high-grades. However, with improved mining, smelting and concentrating methods, much lower grade material became economic, hence these smaller deposits could no longer hold their dominance. Recently the energy crisis and escalating costs of capital for large projects has made smaller deposits attractive once more (Temblay and Descarreaux, 1978) . At the present time gold, tin and tungsten command high prices on world markets. It is for these reasons that a study of the evaluation techniques pertaining to these deposits has been undertaken. In this review the geological factors which influence the evaluation are stressed. In particular, emphasis is placed on the emplacement of vein deposits, and the subsequent chemical and structural modifications of these deposits. The latter part of the review concentrates on the limitations of the sampling and ore reserve techniques that can be applied to the evaluation of mineralized veins. In the conclusion those techniques that are most applicable are stressed, and an evaluation model is outlined.

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado. / Empirical methods play an important role in the field of geomechanics due to the recognized complexity of the nature of rock mass. This study aims to analyze the applicability of empirical design methods in vein-shaped hydrothermal mining deposits (narrow vein) using Bieniawski and Barton classification systems, Mathews stability graphs, Potvin and Mawdesley geomechanics classification systems, and mining pit dilution based on the equivalent linear overbreak/slough (ELOS). In most cases, these methods are applied without understanding the underlying assumptions and limits of the database in relation to the inherent hidden risks. Herein, the dilutions obtained using the empirical methods oscillate between 8% and 11% (according to the frontal dimension), which are inferior to the operative dilution of the mine at 15%. The proposed model can be used as a practical tool to predict and reduce dilution in narrow veins.

The Ras superfamily of GTPases are important regulators of morphogenesis involved in control of cytoskeletal dynamics, intracellular trafficking, apical-basal polarity and cell migration. Mis-regulation of GTPase signaling interferes with development and is linked to pathogenesis. Traditionally, GTPase signaling has been depicted as a series of independent linear pathways. However, recently it has become apparent that multiple GTPases can interact to regulate a single cellular process, functioning in poorly understood networks of cross talk between pathways during development. Jim Fristrom (unpublished data) identified a mutation (18-5) that interacts with components of the GTPases Rho1, Rala, and Cdc42 signaling in multiple developmental contexts. Genetic analysis, physical mapping studies, and sequencing of the mutant allele have indicated that the gene was an allele of GEFmeso (CG30115), which encodes guanine nucleotide exchange factor. To show that 18-5 is an allele of GEFmeso, I demonstrated that a GEFmeso transgene could functionally rescue developmental defects associated with the 18-5 mutation. I also investigated cross talk and network variation in signaling interactions between GEFmeso and other GTPase signaling components in the Drosophila wing. My data provide evidence for microenvironment-dependent variation in GTPase signaling networks in specific domains of the wing, and reveal intercellular variation in GTPase signaling within an otherwise uniform epithelium.