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Regulation and functional profile of cyclic AMP response element-binding protein in monkey primary visual cortex during postnatal development and activity-dependent plasticityLalonde, Jasmin. January 2007 (has links)
No description available.
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MULTISCALE FUNCTIONAL ARCHITECTURE OF NEOCORTEX: FROM CLUSTERS TO COLUMNSUnknown Date (has links)
The physical architecture of neural circuits is thought to underlie the computations that give rise to higher order feature sensitivity in the neocortex. Recent technological breakthroughs have allowed the structural and functional investigation of the basic computational units of neural circuits; individual synaptic connections. However, it remains unclear how cortical neurons sample and integrate the thousands of synaptic inputs, supplied by different brain structures, to achieve feature selectivity. Here, I first describe how visual cortical circuits transform the elementary inputs supplied by the periphery into highly diverse, but well-organized, feature representations. By combining and optimizing newly developed techniques to map the functional synaptic connections with defined sources of inputs, I show that the intersection between columnar architecture and dendritic sampling strategies can lead to the selectivity properties of individual neurons: First, in the canonical feedforward circuit, the basal dendrites of a pyramidal neuron utilize unique strategies to sample ON (light increment) and OFF (light decrement) inputs in orientation columns to create the distinctive receptive field structure that is responsible for basic sensitivity to visual spatial location, orientation, spatial frequency, and phase. Second, for long-range horizontal connections, apical dendrites unbiasedly integrate functionally specialized and spatially targeted inputs in different orientation columns, which generates specific axial surround modulation of the receptive field. / Includes bibliography. / Dissertation (Ph.D.)--Florida Atlantic University, 2019. / FAU Electronic Theses and Dissertations Collection
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The properties of collinear facilitation in human vision /Huang, Pi-Chun, 1975- January 2007 (has links)
The detection threshold of a luminance-defined Gabor is improved by two high contrast, aligned flanking Gabors, an effect termed collinear facilitation. However, the neural basis of collinear facilitation is not well understood. This thesis focuses on a number of issues in collinear facilitation to better our understanding of its neural basis. (1) Cortical sites: the cortical site of collinear facilitation was investigated, and results showed that collinear facilitation is a purely monocular phenomenon. (2) Temporal properties: Collinear facilitation has fast dynamics for initiation and once collinear facilitation occurs it either decays slowly or is associated with a sustained detection. (3) Selectivity to other types of stimuli: chromatic stimuli (which isolated the S-cone opponent and the L/M cone opponent mechanisms) and 2nd order stimuli (a 2D white noise or ID noise multiplied with a Gabor envelope) were used and the results showed that collinear facilitation occurs in chromatic processing, and that some 2nd order stimuli also exhibit collinear facilitation. However, there was no interaction between luminance and chromatic systems nor between 1st and 2nd order mechanisms, suggesting independent processing streams for collinear facilitation. All of these results supported the conclusion that collinear facilitation is not a general property of cortical neurons in V1 since most V1 neurons are binocular, sensitive to both chromatic and achromatic stimuli and sensitive to both 1 st and 2nd order stimuli. Furthermore, the temporal properties of collinear facilitation suggest complex dynamic interactions, not simply explained by the passive propagation of long-range recurrent intra-cortical connections between flanks and target.
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The properties of collinear facilitation in human vision /Huang, Pi-Chun, 1975- January 2007 (has links)
No description available.
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The expression of neurofilament protein and mRNA levels in the lateral geniculate nucleus and area V1 of the developing and adult vervet monkey (Ceorcopithicus aethiops) /Kogan, Cary. January 1999 (has links)
This study comprised three questions, each posed with the intention of exploring the expression of the neurofilament protein (NF) and mRNA levels in the monkey lateral geniculate nucleus (LGN) and visual cortex. (1) Literature indicates NFs are differentially expressed across the two visual pathways that originate from magnocellular and parvocellular layers in LGN. The results herein suggest that this difference continues at the level of gene transcription for the neurofilament heavy gene. (2) NF expression, assessed by SMI-32 (an antibody that recognizes an epitope of the non-phosphorylated NFs), was investigated as a function of developmental changes occurring during the critical period in area V1 of the vervet monkey visual cortex. The findings indicate that the M pathway develops before the P pathway. (3) The effect of eye enucleation on long-term changes in NF expression was investigated. The results do not support the idea that NF are activity-dependent.
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Ordering geniculate input into primary visual cortexKrug, Kristine January 1997 (has links)
Precise point-to-point connectivity is the basis of ordered maps of the visual field in the brain. One point in the visual field is represented at one locus in the dLGN and one locus in primary visual cortex. A fundamental problem in the development of most sensory systems is the creation of the topographic projections which underlie these maps. Mechanisms ranging from ordered ingrowth of fibres, through chemical guidance of axons to sculpting of the map from an early exuberant input have been proposed. However, we know little about how ordered maps are created beyond the first relay. What we do know is that a topological mismatch requires the exchange of neighbours in the geniculo-cortical projection and that manipulating the input to the primary relay can affect the geniculo-cortical topography. Taking advantage of the immaturity of the newborn hamsterâs visual system, I studied the generation of an ordered map in primary visual cortex during the time of target innervation in normal and manipulated animals. I also investigated the patterning of neuronal activity prior to natural eye-opening. Paired injections of retrograde fluorescent tracers into visual cortex reveal that geniculate fibres are highly disordered at the time of invasion of the cortical plate. Topography in the geniculo-cortical projection emerges out of an unordered projection to area 17 in the first postnatal week. Furthermore, I show that manipulating the peripheral input can alter the topographic map which arises out of the early scatter. Removal of one eye at birth appears to slow the process of geniculo-cortical map formation ipsilateral to the remaining eye and at the end of the second postnatal week, a double projection between thalamus and cortex has formed. If retinal activity is blocked during this time, this double projection does not emerge. The results implicate retinal activity as the signal that induces the development of a different topographic order in the geniculo-cortical projection. It is generally believed that visual experience can influence development only after eye-opening. However, the final part of my thesis shows that neurons in the developing visual cortex of the ferret can not only be visually driven at least 10 days before natural eye-opening, but are also selective for differently oriented gratings presented <i>through the closed eye-lid</i>. Thus, visually-driven neuronal activity could influence development much earlier than previously assumed in many developmental studies.
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Processing of transient stimuli by the visual system of the ratKara, Prakash January 1993 (has links)
While three decades of intensive cortical electrophysiology using a variety of sustained visual stimuli has made a significant contribution to many aspects of visual function, it has not supported the existence of intracortical circuit operations in cortical processing. This study investigated cortical processing by a comparison of the response of primary visual cortical neurones to transient electrical and strobe-flash stimulation. Experiments were performed on 74 anaesthetised Long Evans rats. Standard stereotaxic and extracellular electrophysiological techniques were employed. Continuous (on-line) raster plots and peri-stimulus time histograms (PSTHs) of the extracellular spikes from 81 visual cortical and 55 lateral geniculate nucleus (LGN) neurones were compiled. The strobe-flash stimuli (0.05 ms) were applied to the contralateral eye while the monopolar or bipolar electrical stimuli (0.2 ms, 80-400 μA) were applied to the ipsilateral LGN. 60 of the 81 (74%) tested cortical units were found to be responsive to visual stimuli. A distinct and consistent difference in the cortical response to the two types of transient stimuli was found: (a) Electrical stimulation evoked a prolonged period (197 ± 61 ms) of inhibition in all cortical neurones tested (n=20). This was the case even in those cortical units that were completely unresponsive to visual stimulation. The protracted inhibition was usually followed by a 100-200 ms phase of rebound excitation. (b) Flash stimulation evoked a prominent excitatory discharge (5-30 ms duration) after a latency of 30-60 ms from the onset of the stimulus (n = 59). This was followed by either moderate inhibition or return to a firing rate similar to control activity, for a maximum of 40 ms. Thereafter, cortical neurones showed a sustained increased level of activity with superimposed secondary excitatory phases. The duration of this late re-excitatory phase was 200-300 ms. In 17 of 20 (85%) tested units, the temporal profile of the cortical response to flash stimulation was modulated by small changes in the level of background illumination. In 16 of the 17 units, this sensitivity was reflected primarily as an emergence of a brief secondary inhibitory phase at the lowest level of background illumination (0 lux). Only 1 of the 17 cortical units displayed a flash-evoked primary inhibitory phase at O lux. We explored the possibility that neurones in the lateral geniculate nucleus (LGN) of the thalamus were responsible for the late phase of cortical reexcitation. 49 of the 55 (89%) LGN neurones could be classified as either of the "ON type" i.e. excited by visual stimuli, or the "OFF type" i.e. inhibited by visual stimuli. The response of ON-like LGN neurones to strobe-flash stimulation of the contralateral eye was characterised by a primary excitatory or early discharge (ED) phase after a latency of 25-40 ms. Thereafter, a 200- 400 ms period of inhibition was observed. In 57% of the sample, a rebound excitatory or late discharge (LD) phase completed the response. OFF-like LGN neurones were inhibited by the strobe-flash stimuli after a latency of 30- 35 ms. This flash-evoked inhibition was maintained for 200-400 ms. The sensitivity of the flash-evoked LGN response to the level of background illumination was tested in 11 ON-like and 10 OFF-like neurones. No sustained secondary excitatory events, as observed in visual cortical neurones, were found in any of the ON- and OFF-like LGN neurones, irrespective of the level of background illumination. In conclusion, the data show that the late re-excitatory phase evoked in cortical neurones upon strobe-flash stimulation, is not due to sustained LGN (thalamic) input. Rather, it suggests that these re-excitatory phases are due to intracortical processing of the transient stimuli. These findings emphasize the independent role of the cortex in computing the response to visual stimuli, and cast doubt on traditional theories that have emphasised the role of the thalamus in shaping cortical responses. The difference in the flash and electrically evoked cortical response suggests that even though substantial inhibition is available to the cortex, only a small fraction of this inhibitory capacity is utilised during natural stimulation.
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The expression of neurofilament protein and mRNA levels in the lateral geniculate nucleus and area V1 of the developing and adult vervet monkey (Ceorcopithicus aethiops) /Kogan, Cary. January 1999 (has links)
No description available.
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Bilateral distribution of face- and object-selective neurones in the adult vervet monkey inferotemporal cortex : a molecular mapping studyZangenehpour, Shahin January 2003 (has links)
A series of studies is described here which explore the functional organisation of face- and object-processing neurones in the adult vervet monkey brain. This fundamental issue in high-level vision is addressed by the use of a novel molecular mapping technique that was developed for this purpose. / In the first study, the temporal dynamics of c-fos and zif268 expression were delineated in detail in the rat visual cortex. Knowing the precise temporal parameters of up-regulation (after onset of sensory stimulation) and down-regulation (after offset of sensory stimulation) of these genes was integral to optimising the temporal aspects of the stimuli to be used for subsequent mapping experiments. This study provided the critical information for devising stimuli with corresponding temporal parameters to those of c-fos or zif268 so that one could take advantage of the disparity between the expression of their mRNA and protein products in order to visualise activated neurones. / In the second study, the newly developed molecular mapping technique was validated in the rat auditory, visual and multisensory systems. First, bimodal audiovisual stimuli were designed using the data obtained from the first study. Then, through the combined histological detection of the mRNA and protein products of zif268, discrete populations of neurones responsive to either component of the bimodal stimulus were visualised. It was also observed that a third population of neurones was found that responded to the stimulation through both sensory modalities. The combined results from these two studies set the stage for addressing the issue of the organisation of face- and object-selective neurones of the inferior temporal cortex in the vervet monkey brain. / In the third study, the functional organisation of face- and object-selective neurones was examined using the molecular mapping technique. Based on the data gathered from the first two studies, suitable stimuli containing two distinct object classes (conspecific faces and non-face familiar objects) were designed with appropriate temporal parameters. / Finally, the last study provided an opportunity to address the issue of hemispheric asymmetry of function in the context of face processing in the non-human primate brain. Results support the notion that there may indeed be phylogenetic explanations for the hemispheric asymmetry observed in the human brain.
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Bilateral distribution of face- and object-selective neurones in the adult vervet monkey inferotemporal cortex : a molecular mapping studyZangenehpour, Shahin January 2003 (has links)
No description available.
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