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191	Compartmentalisation of retinoic acid synthesis in neuronal cells, and the role of RA in the control of melatonin synthesis by the pineal gland Ransom, Jemma S. January 2012 (has links) During embryogenesis, vitamin A metabolism to retinoic acid (RA) is tightly regulated in a precise spatiotemporal pattern. Aberrant retinoid signalling in the wrong place or at the wrong time has devastating consequences for development. Much is understood about the mechanisms by which at the level of specific tissues, RA synthesis from vitamin A is able to occur and activate target genes necessary for the developmental programme at any given stage. However, little is known about how retinoid transport and synthesis at the subcellular level occurs. Chapter 3 of this thesis investigates the subcellular compartments with which the vitamin A metabolising enzyme RALDH2 associates in embryonic neuronal cell lines. It is found that not only is RA synthesis tightly controlled by tissues, but that RA signalling within cells themselves may also be segmented. Aside from the importance of vitamin A during early development, it is now known that this dietary component is also vital in the maintenance of homeostasis during adulthood. This is particularly important for the adult CNS, where it is proposed that RA mediates hippocampal neurogenesis; hypothalamic neurogenesis; and physiological responses to seasonal changes in day length. The nocturnal hormone melatonin is a key signalling molecule relaying the length of the night to the rest of the brain and periphery, and by this means conveying information about the time of year. Vitamin A deficiency is known to severely reduce the amount of melatonin produced by the Quail pineal gland at night. Chapter 4 of this thesis investigates the circadian and circannual rhythms of retinoid genes such as the RALDH enzymes and retinoic acid receptors in both the SCN, and the pineal gland. RA is sufficient to increase the expression of the melatonin synthesising enzyme AANAT, and that this gene expression may be under the control of RALDH1. 610 Melatonin ; Vitamin A ; Tretinoin
192	Determination of 1 ,25-dihydroxy calciferol Abellana, Jocelyn A. January 1984 (has links) published_or_final_version / Medical Sciences / Master / Master of Medical Sciences Vitamin D - Metabolism.
193	Syntheses and reactions of polyvinylthiazoles Schilling, Curtis Louis, 1940- January 1967 (has links) No description available. Vitamin B1. Polymers. Polymerization.
194	ENVIRONMENTAL AND GENETIC INFLUENCES UPON HEPATIC AND PLASMA VITAMIN A AND CAROTENE LEVELS IN RANGE CATTLE Diven, Richard Harlan, 1933- January 1959 (has links) No description available. Vitamin A. Carotenes. Cattle -- Metabolism.
195	NUTRITIONAL, ENVIRONMENTAL AND ENDOCRINOLOGICAL FACTORS AFFECTING THE EFFICIENCY OF UTILIZATION OF VITAMIN A AND CAROTENE BY VITAMIN A-DEFICIENT RATS AND RUMINANTS Anderson, Thomas A. (Thomas Alexander), 1928- January 1962 (has links) No description available. Carotenes -- Metabolism. Vitamin A deficiency.
196	1α,25-DIHYDROXYVITAMIN D₃ RECEPTORS IN INTESTINE: PROPERTIES AND UTILIZATION IN AN ASSAY FOR THIS STEROL HORMONE Brumbaugh, Peter Flory, 1949- January 1975 (has links) No description available. Vitamin D. Intestines.
197	Hydroxylation of aromatic compounds by a synthetic analog of an enzyme system Michelson, Malvin Jay, 1933- January 1957 (has links) No description available. Vitamin C. Aromatic compounds.
198	Enzyme activity changes in vitamin Bb6s deficiency Jackson, Noble, 1952- January 1976 (has links) No description available. Vitamin B6 deficiency.
199	The effect of ambient temperatures and solar radiation on vitamin A metabolism and certain blood constituents in the bovine animal Page, Harold Monroe, 1929- January 1959 (has links) No description available. Vitamin A -- Metabolism. Cattle -- Metabolism.
200	The homeostatic control of the kidney 25-hydroxyvitamin D₃1α-hydroxylase Cork, Douglas James, 1950- January 1974 (has links) No description available. Vitamin D in the body. Homeostasis.

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