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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Developing Pulsatile Flow in a Deployed Coronary Stent

Rajamohan, Divakar January 2005 (has links)
No description available.
12

Design of Gages for Direct Skin Friction Measurements in Complex Turbulent Flows with Shock Impingement Compensation

Rolling, August Jameson 05 July 2007 (has links)
This research produced a new class of skin friction gages that measures wall shear even in shock environments. One test specimen separately measured wall shear and variable-pressure induced moment. Through the investigation of available computational modeling methods, techniques for accurately predicting gage physical responses were developed. The culmination of these model combinations was a design optimization procedure. This procedure was applied to three disparate test conditions: 1) short-duration, high-enthalpy testing, 2) blow-down testing, and 3) flight testing. The resulting optimized gage designs were virtually tested against each set of nominal load conditions. The finalized designs each successfully met their respective test condition constraints while maximizing strain output due to wall shear. These gages limit sources of apparent strain: inertia, temperature gradient, and uniform pressure. A unique use of bellows provided a protective shroud for surface strain gages. Oil fill provided thermal and dynamic damping while eliminating uniform pressure as a source of output voltage. Two Wheatstone bridge configurations were developed to minimize temperature effects first from temperature gradient and then from spatially varying heat flux induced gradient. An inertia limiting technique was developed that parametrically investigated mass and center of gravity impact on strain output. Multiple disciplinary computational simulations of thermal, dynamic, shear, moment, inertia, and instrumentation interaction were developed. Examinations of instrumentation error, settling time, filtering, multiple input dynamic response, and strain gage placement to avoid thermal gradient were conducted. Detailed mechanical drawings for several gages were produced for fabrication and future testing. / Ph. D.
13

Design, Analysis, and Initial Testing of a Fiber-Optic Shear Gage for 3D, High-Temperature Flows

Orr, Matthew William 10 February 2004 (has links)
This investigation concerns the design, analysis, and initial testing of a new, two-component wall shear gage for 3D, high-temperature flows. This gage is a direct-measuring, non-nulling design with a round head surrounded by a small gap. Two flexure wheels are used to allow small motions of the floating head. Fiber-optic displacement sensors measure how far the polished faces of counterweights on the wheels move in relation to a fixed housing as the primary measurement system. No viscous damping was required. The gage has both fiber-optic instrumentation and strain gages mounted on the flexures for validation of the newer fiber optics. The sensor is constructed of Haynes 230, a high-temperature nickel alloy. The gage housing is made of 316 stainless steel. All components of the gage in pure fiber-optic form can survive to a temperature of 1073 K. The bonding methods of the backup strain gages limit their maximum temperature to 473 K. The dynamic range of the gage is from 0-500 Pa (0-10g) and higher shears can be measured by changing the floating head size. Extensive use of finite element modeling was critical to the design and analysis of the gage. Static structural, modal, and thermal analyses were performed on the flexures using the ANSYS finite element package. Static finite element analysis predicted the response of the flexures to a given load, and static calibrations using a direct force method confirmed these results. Finite element modal analysis results were within 16.4% for the first mode and within 30% for the second mode when compared with the experimentally determined modes. Vibration characteristics of the gage were determined from experimental free vibration data after the gage was subjected to an impulse. Uncertainties in the finished geometry make this level of error acceptable. A transient thermal analysis examined the effects of a very high heat flux on the exposed head of the gage. The 100,000 W/m2 heat flux used in this analysis is typical of a value in a scramjet engine. The gage can survive for 10 minutes and operate for 3 minutes before a 10% loss in flexure stiffness occurs under these conditions. Repeated cold-flow wind tunnel tests at Mach 2.4 with a stagnation pressure from 3.7-8.2 atm (55-120 psia) and ambient stagnation temperature (Re=6.6x107/m) and Mach 4.0 with a stagnation pressure from 10.2-12.2 atm (150-180 psia) and ambient stagnation temperature (Re=7.4x107/m) were performed in the Virginia Tech Supersonic Wind Tunnel. Some of these tests had the gage intentionally misaligned by 25o to create a virtual 3D flow in this nominally 2D facility. Experimental results gave excellent agreement with semi-empirical prediction methods for both the aligned and 25o experiments. This fiber-optic skin friction gage operated successfully without viscous damping. These tests in the supersonic wind tunnel validated this wall shear gage design concept. / Ph. D.
14

Integration and Validation of Flow Image Quantification (Flow-IQ) System

Carneal, Jason Bradley 25 October 2004 (has links)
The first aim of this work was to integrate, validate, and document, a digital particle image quantification (Flow-IQ) software package developed in conjunction with and supported by Aeroprobe Corporation. The system is tailored towards experimental fluid mechanics applications. The second aim of this work was to test the performance of DPIV algorithms in wall shear flows, and to test the performance of several particle sizing algorithms for use in spray sizing and average diameter calculation. Several particle sizing algorithms which assume a circular particle profile were tested with DPIV data on spray atomization, including three point Guassian, four point Gaussian, and least squares algorithms. A novel elliptical diameter estimation scheme was developed which does not limit the measurement to circular patterns. The elliptic estimator developed in this work is able to estimate the diameter of a particle with an elliptic shape, and assumes that the particle is axisymmetric about the x or y axis. Two elliptical schemes, the true and averaged elliptical estimators, were developed and compared to the traditional three point Gaussian diameter estimator using theoretical models. If elliptical particles are theoretically used, the elliptical sizing schemes perform drastically better than the traditional scheme, which is limited to diameter measurements in the x-direction. The error of the traditional method in determining the volume of an elliptical particle increases dramatically with the eccentricity. Monte Carlo Simulations were also used to characterize the error associated with wall shear measurements using DPIV. Couette flow artificial images were generated with various shear rates at the wall. DPIV analysis was performed on these images using PIV algorithms developed by other researchers, including the traditional multigrid method, a dynamically-adaptive DPIV scheme, and a control set with no discrete window offset. The error at the wall was calculated for each data set. The dynamically adaptive scheme was found to estimate the velocity near the wall with less error than the no discrete window offset and traditional multigrid algorithms. The shear rate was found to be the main factor in the error in the velocity measurement. In wall shear velocity measurement, the mean (bias) error was an order of magnitude greater than the RMS (random) error. A least squares scheme was used to correct for this bias error with favorable results. The major contribution of this effort stems from providing a novel elliptical particle sizing scheme for use in DPIV, and quantifies the error associated with wall shear measurements using several DPIV algorithms. A test bed and comprehensive user's manual for Flow-IQ v2.2 was also developed in this work. / Master of Science
15

A Study of Direct Measuring Skin Friction Gages for High Enthalpy Flow Applications

Meritt, Ryan James 11 June 2010 (has links)
This study concerns the design, analysis, and initial testing of a novel skin friction gage for applications in three-dimensional, high-speed, high-enthalpy flows. Design conditions required favorable gage performance in the Arc-Heated Facilities at Arnold Engineering Development Center. Flow conditions are expected to be at Mach 3.4, with convective heat properties of h= 1,500 W/(m°·K) (264 Btu/(hr·ft°·°R)) and T_aw= 3,900 K (7,000 °R). The wall shear stress is expected to be as high as τ_w= 2,750 Pa (0.40 psi) with a correlating coefficient of skin friction value around C_f= 0.0035. Through finite element model and analytical analyses, a generic gage design is predicted to remain fully functional and within reasonable factors of safety for short duration tests. The deflection of the sensing head does not exceed 0.025 mm (0.0001 in). Surfaces exposed to the flow reach a maximum temperatures of 960 K (1,720 °R) and the region near the sensitive electronic components experience a negligible rise in temperature after a one second test run. The gage is a direct-measuring, non-nulling design in a cantilever beam arrangement. The sensing head is flush with the surrounding surface of the wall and is separated by a small gap, approximately 0.127 mm (0.005 in). A dual-axis, semi-conductor strain gage unit measures the strain in the beam resulting from the shear stress experienced by the head due to the flow. The gage design incorporates a unique bellows system as a shroud to contain the oil filling and protect the strain gages. Oil filling provides dynamic and thermal damping while eliminating uniform pressure loading. An active water-cooling system is routed externally around the housing in order to control the temperature of the gage system and electronic components. Each gage is wired in a full-bridge Wheatstone configuration and is calibrated for temperature compensation to minimize temperature effects. Design verification was conducted in the Virginia Tech Hypersonic Tunnel. The gage was tested in well-documented Mach 3.0, cold and hot flow environments. The tunnel provided stagnation temperatures and pressures of up to T₀= 655 K (1,180 °R) and P₀= 1,020 kPa (148 psi) respectively. The local wall temperatures ranged from T_w= 292 to 320 K (525 to 576 °R). The skin friction coefficient measurements were between 0.00118 and 0.00134 with an uncertainty of less than 5%. Results were shown to be repeatable and in good concurrence with analytical predictions. The design concept of the gage proved to be very sound in heated, supersonic flow. When it worked, it did so very effectively. Unfortunately, the implementation of the concept is still not robust enough for routine use. The strain gage units in general were often unstable and proved to be insufficiently reliable. The detailed gage design as built was subject to many potential sources of assembly misalignment and machining tolerances, and was susceptible to pre-loading. Further recommendations are provided for a better implementation of this design concept to make a fully functional gage test ready for Arnold Engineering Development Center. / Master of Science
16

Study of Skin Friction and Surface Regression Interaction via the Naphthalene Sublimation Technique

Hall, Grace Alexandra 22 February 2023 (has links)
This study explores the potential of the naphthalene sublimation technique to be used to analyze the manner in which surfaces regress, specifically focusing on the effect that skin friction has on regression and vice versa. For this experimentation, a flat steel plate installed with three skin friction sensors was coated with naphthalene via a mechanized sprayer and was installed in the wall of the Ahmic Aerospace Turbulent Boundary Layer Research supersonic wind tunnel. The plate and sensor configuration was subjected to three subsequent tunnel runs at Mach 2.31. This process was repeated at plenum pressures of 0.35 MPa and 0.69 MPa, which correspond to Reynolds Numbers of 1.4x10^7/m and 2.8x10^7/m. Between the first and final run, a -4.7% and -3.7% percent change in the coefficient of friction was seen at the 0.35 MPa and 0.69 MPa plenum conditions, respectively. Images of the plate taken before and after each run qualitatively indicate continual naphthalene regression with each subsequent tunnel run. This decrease in the coefficient of friction was attributed in part to the regression of the naphthalene coating, indicating that this method has the potential to be used to study the interaction between skin friction and regressing surfaces. Additionally, this study showed that it is certainly possible to measure skin friction with sensors where both the head of the movable sensor element and the surrounding wall is coated with sprayed naphthalene. / Master of Science / This study explores the potential of using an experimental method to better understand how surfaces recede when subjected to moving air. A chemical called naphthalene was used because naphthalene naturally recedes very easily, unlike many other materials which a researcher would want to study the receding behavior of, making it an ideal choice for this study. Sensors made to detect the amount of force generated by flowing air over a surface were installed into a flat metal plate. The plate was coated with naphthalene and installed into the wall of a wind tunnel, which generates airflow over the plate to simulate flight conditions. Three separate and sequential airflow runs over the plate were conducted. This process was repeated under two different air conditions. In both conditions, a decrease in the amount of force due to the air moving over the plate was detected as subsequent runs were conducted and the naphthalene receded. This indicates the method has the potential to be used to study how other surfaces recede when subjected to moving air.
17

Skin Friction Sensor Design Methodology and Validation for High-Speed, High-Enthalpy Flow Applications

Meritt, Ryan James 24 January 2014 (has links)
This investigation concerns the design, build, and testing of a new class of skin friction sensor capable of performing favorably in high-speed, high-enthalpy flow conditions, such as that found in atmospheric re-entry vehicles, scramjets, jet engines, material testing, and industrial processes. Fully understanding and optimizing these complex flows requires an understanding of aerodynamic properties at high enthalpies, which, in turn, requires numerical and analytical modeling as well as reliable diagnostic instrumentation. Skin friction is a key quantity in assessing the overall flight and engine performance, and also plays an important role in identifying and correcting problem areas. The sensor design is founded on a direct-measuring, cantilever arrangement. The design incorporates two fundamental types of materials in regards to thermal conductivity and voltage resistivity properties. The non-conducting material distinction greatly deters the effect of heat soak and prevents EMI transmission throughout the sensor. Four custom fabricated metal-foil strain gauges are arranged in a Wheatstone bridge configuration to increase sensitivity and to provide further compensation for sensitivity effects. The sensor is actively cooled via a copper water channel to minimize the temperature gradient across the electronic systems. The design offers a unique immunity to many of the interfering influences found in complex, high-speed, high-enthalpy flows that would otherwise overshadow the desired wall shear measurement. The need to develop an encompassing design methodology was recognized and became a principal focus of this research effort. The sensor design was developed through a refined, multi-disciplinary approach. Concepts were matured through an extensive and iterative program of evolving key performance parameters. Extensive use of finite element analysis (FEA) was critical to the design and analysis of the sensor. A software package was developed to utilize the powerful advantage of FEA methods and optimization techniques over the traditional trial and error methods. Each sensor endured a thorough series of calibrations designed to systematically evaluate individual aspects of its functionality in static, dynamic, pressure, and thermal responses. Bench-test facilities at Virginia Tech (VT) and Air Force Research Laboratory (AFRL) further characterized the design vibrational effects and electromagnetic interference countermeasure effectiveness. Through iterations of past designs, sources of error have been identified, controlled, and minimized. The total uncertainty of the skin friction sensor measurement capability was determined to be ±8.7% at 95% confidence and remained fairly independent of each test facility. A rigorous, multi-step approach was developed to systematically test the skin friction sensor in various facilities, where flow enthalpy and run duration were progressively increased. Initial validation testing was conducted at the VT Hypersonic Tunnel. Testing at AFRL was first performed in the RC-19 facility under high-temperature, mixing flow conditions. Final testing was conducted under simulated scramjet flight conditions in the AFRL RC-18 facility. Performance of the skin friction sensors was thoroughly analyzed across all three facilities. The flow stagnation enthalpies upward of 1053 kJ/kg (453 Btu/lbm) were tested. A nominal Mach 2.0 to 3.0 flow speed range was studied and stagnation pressure ranged from 172 to 995 kPa (25 to 144 psia). Wall shear was measured between 94 and 750 Pa (1.96 and 15.7 psf). Multiple entries were conducted at each condition with good repeatability at ±5% variation. The sensor was also able to clearly indicate the transient flow conditions of a full scramjet combustion operability cycle to include shock train movement and backflow along the isolator wall. The measured experimental wall shear data demonstrated good agreement with simple, flat-plate analytical estimations and historic data (where available). Numerical CFD predictions of the scramjet flow path gave favorable results for steady cold and hot flow conditions, but had to be refined to handle the various fueling injection schemes with burning in the downstream combustor and surface roughness models. In comparing CFD wall shear predictions to the experimental measurements, in a few cases, the sensor measurement was adversely affected by shock and complex flow interaction. This made comparisons difficult for these cases. The sensor maintained full functionality under sustained high-enthalpy conditions. No degradation in performance was noted over the course of the tests. This dissertation research and development program has proven successful in advancing the development of a skin friction sensor for applications in high-speed, high-enthalpy flows. The sensor was systematically tested in relevant, high-fidelity laboratory environments to demonstrate its technology readiness and to successfully achieve a technology readiness level (TRL) 6 milestone. The instrumentation technology is currently being transitioned from laboratory development to the end users in the hypersonic test community. / Ph. D.
18

Mechanical Stresses on Nasal Mucosa Using Nose-On-Chip Model

Brooks, Zachary Edward January 2019 (has links)
No description available.
19

On the assessment of blood velocity and wall shear rate in arteries with Doppler ultrasound : a validation study

Blake, James R. January 2008 (has links)
Cardiovascular disease, mostly atherosclerosis, is responsible for one third of all deaths globally, rising to more than 50% in the Western World. Risk factors include smoking, diet, and familial history. Doppler ultrasound can provide estimates of blood velocity and wall shear rate. Clinically, maximum velocity is used to categorise patients for surgery, although Doppler velocity measurement is prone to errors and in need of validation. Wall shear stress—which can be derived from wall shear rate—plays a role in disease initiation and progression, although its clinical utility is unclear due to difficulties associated with its measurement. This thesis investigates the use of Doppler ultrasound as a tool to estimate blood velocity and wall shear rate. A simplified method for estimation of wall shear rate in healthy arteries is developed that uses spectral Doppler ultrasound. This method is based upon the theory of oscillatory flow in rigid pipes, requiring two measurements that are readily available with clinical ultrasound machines. This method is compared to a similar method based on colour flow imaging. The spectral Doppler method underestimated the theoretic value of wall shear rate by between 7 and 22%, with results varying between phantoms. Errors for the colour method were on average 35% greater. Test measurements from one healthy volunteer demonstrated that this method can be applied in-vivo. In more advanced stages of disease, peak velocity distal to a stenosis is of clinical interest and the simplified method for wall shear rate estimation is invalid. Steady flow in a series of simplified stenosis geometries was studied using a dual-beam Doppler system to obtain velocity vectors. These measurements were compared with data from an equivalent system that used particle image velocimetry (PIV) and was considered the gold standard. For Reynolds numbers at the stenosis throat of less than 800, flow remained laminar over the region studied, although distal flow separation did occur. For higher throat Reynolds numbers—corresponding to more severe stenoses or increased flow rates—asymmetric recirculation regions developed; the transition to turbulence occurred more proximally, with a corresponding reduction in stenotic jet and recirculation length. Qualitative agreement was observed in the velocity profile shapes measured using ultrasound and PIV at throat Reynolds numbers less than 800. Above this threshold the qualitative agreement between the velocity profiles became poorer as both downstream distance and the degree of stenosis increased. Peak axial velocity distal to the stenosis was underestimated, on average, by 15% in the ultrasound system. Estimation of shear rate remained difficult with both experimental techniques. Under a Newtonian approximation, the normalised wall shear stresses agree qualitatively. Under pulsatile flow conditions using an idealised flow waveform, superior qualitative agreement was observed in the velocity profiles at diastole than at systole. Similar to the steady flow behaviour, this agreement deteriorated with stenosis severity. The current generation of clinical ultrasound machines are capable of estimating the wall shear rate in healthy arteries. In the presence of significant arterial disease, errors in the peak velocity may result in mis-selection of patients for surgery, while estimation of the wall shear stress remains extremely problematic; particularly with identifying the wall location and measuring velocities close to the wall.
20

Development of Particle Image Velocimetry for In-Vitro Studies of Arterial Haemodynamics

Buchmann, Nicolas January 2010 (has links)
Atherosclerosis and related cardiovascular diseases (CVDs) are amongst the largest causes of morbidity and mortality in the developed world, causing considerable monetary pressure on public health systems worldwide. Atherosclerosis is characterised by the build up of vascular plaque in medium and large arteries and is a direct precursor to acute vascular syndromes such a myocardial infarction, stroke or peripheral arterial diseases. The causative factors leading to CVD still remain relatively poorly understood, but are becoming increasingly identifiable as a dysfunction of the endothelial cells that line the arterial wall. It is well known that the endothelium responds to the prevailing fluid mechanic (i.e. haemodynamic) environment, which plays a crucial role in the localised occurrence of atherosclerosis near vessel bends and bifurcations. In these areas, disturbed haemodynamics lead to flow separation and very low wall shear stress (WSS), which directly affects the functionality of the endothelium and impedes the transport of important blood borne agonists and antagonists. Detailed full field measurements assessing complex haemodynamics are sparse and consequently this thesis aims to address some of the important questions related to arterial haemodynamics and CVD by performing in-vitro flow measurements in physiologically relevant conditions. In particular, this research develops and uses state-of-the-art Particle Image Velocimetry (PIV) techniques to measure three-dimensional velocity and WSS fields in scaled models of the human carotid artery. For this purpose, the necessary theoretical and experimental concepts are developed and in-depth analyses of the underlying factors affecting the local haemodynamics and their relation to CVD are carried out. In the first part, a methodology for the construct of transparent hydraulic flow phantoms from medical imaging data is developed. The arterial geometries are reproduced in optically clear silicone and the flowing blood is modelled with a refractive index matched blood analogue. Subsequently, planar and Stereo-PIV techniques are developed and verified. A novel interfacial PIV (iPIV) technique is introduced to directly measure WSS by inferring the velocity gradient from the recorded particle images. The new technique offers a maximal achievable resolution of 1 pixel and therefore removes the resolution limit near the wall usually associated with PIV. Furthermore, the iPIV performance is assessed on a number of numerical and experimental test cases and iPIV offers a significantly improved measurement accuracy compared to more traditional techniques. Subsequently, the developed methodologies are applied in three studies to characterise the velocity and WSS fields in the human carotid artery under a number of physiological and experimental conditions. The first study focuses on idealised vessel geometries with and without disease and establishes a general understanding of the haemodynamic environment. Secondly, a physiological accurate vessel geometry under pulsatile flow conditions is investigated to provide a more realistic representation of the true in-vivo flow conditions. The prevailing flow structure in both cases is characterised by flow separation, strong secondary flows and large spatial and temporal variations in WSS. Large spatial and temporal differences exist between the different geometries and flow conditions; spatial variations appear to be more significant than transient events. Thirdly, the three-dimensional flow structure in the physiological carotid artery model is investigated by means of stereoscopic and tomographic PIV, permitting for the first time the measurement of the full 3D-3C velocity field and shear stress tensor in such geometries. The flow field within the model is complex and three-dimensional and inherently determined by the vessel geometry and the build up of an adverse pressure gradient. The main features include strong heliocoidal flow motions and large spatial variations in WSS. Lastly, the physiological implications of the current results are discussed in detail and reference to previous work is given. In summary, the present research develops a novel and versatile PIV methodology for haemodynamic in vitro studies and the functionality and accuracy is demonstrated through a number of physiological relevant flow measurements.

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