Strategies to harness the energy from organic waste is gaining importance on a global scale, especially in countries with large quantities of it. In this paper, a techno-economic analysisand a field study were performed to investigate the feasibility of five scenarios for a conceptual biogas facility, based on a case study from Colombia. The plant designs involved anaerobic digestion followed by different combinations of biogas upgrading, combined heat and power and/or steam methane reforming technologies and investigated four different feedstocks. The results demonstrated that the road infrastructure leading to the current proposed site is inadequate, and a new location should be found. Anaerobic digestion alone was most profitable with the shortest payback period. Organic Municipal Solid Waste and Poultry Manure produced high techno-economic potential depending on the scenario. The production of hydrogen using anaerobic digestion, steam methane reforming and combined heat and power with or without upgrading is not recommended due to the current market prices and high heat consumption. However, it can be profitable to implement green energy initiatives as a strategy to establish and lead future energy markets.