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Synthesis and catalysis with poly(ethylene oxide)-substituted triphenylphosphinesPinault, Nathalie January 2000 (has links)
No description available.
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Characterization of the interphase in a model water soluble associative polymer/particle system and its adsorption/desorption behavior /Heck, Connie S., January 1997 (has links)
Thesis (Ph. D.)--Lehigh University, 1997. / Includes vita. Includes bibliographical references.
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Supported catalysts, from polymers to gold nanoparticles supportsSommer, William J. January 2007 (has links)
Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2008. / Christoph J. Fahrni, Committee Member ; Mostapha A. El-Sayed, Committee Member ; Christopher W. Jones, Committee Member ; Marcus Weck, Committee Chair ; E. Kent Barefield, Committee Member.
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Inverse gas chromatographic and static measurements of water-polymer interactions : a thesisAspler, Joseph Stephen January 1980 (has links)
Note:
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Synthesis of water soluble polymer-bound antiproliferative agentsJohnson, Mark Trevor 31 October 2006 (has links)
Student Number : 9903022H
MSc Dissertation
School of Chemistry
Faculty of Science / Cancer is characterised by the unconstrained growth of cancerous cells, which damages
the healthy cells and ultimately the tissue of the host. Chemotherapy forms an essential
component in the treatment of this disease, however most anti-tumour drugs suffer from
various deficiencies, e.g. increased toxicity, reduced serum half life and poor water
solubility. The focus of this project was to address some of these deficiencies by
conjugating selected drugs to a water-soluble polymeric carrier.
Selected water-soluble biodegradable carriers were synthesized. Copolyaspartamides,
polyamidoamines and polyamides were obtained by condensation polymerisation,
Michéal–type addition polymerisation and ester amine base-catalysed polymerisation.
The nascent water soluble polymers were used to conjugate platinum, ferrocene and
tetramethylmelamine derivative, respectively. The percentage drug in each polymer drug
conjugate was determined by considering the mass of the drug in the conjugate as a
percentage of the total mass of the drug-polymer conjugate.
Platinum was linked to the carrier via polymer attached amine, carboxyl and hydroxyl
ligands. Platinum content of the conjugates ranged from 7 to 11 % by mass. The
ferrocenylation agent, 4-ferrocenylbutanoic acid, and the tetramethylmelamine derivative,
3-(4,6-bis(N,N-dimethylamino)-1,3,5-triazacyclohexatrien-2-yl) propanoic acid was
polymer-bound by amidation reactions. Iron content of the ferrocence conjugated ranged
from 2 to 12 % by mass. While the drug content based on tetramethylmelamine in the
3-(4,6-bis[N,N-dimethylamino]-1,3,5-triazacyclohexatrien-2-yl) propanoic acid polymer
conjugate ranged from 8.4 to 8.6 % by mass. There was a preliminary attempt to coconjugate
both, 4-ferrocenylbutanoic acid and 3-(4,6-bis[N,N-dimethylamino]-1,3,5-
triazacyclohexatrien-2-yl) propanoic acid to the same polymer. This co-conjugate
contained 2.9 % iron and 3.4 % tetramethylmelamine by mass.
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Synthesis and Solution Behavior of Doubly Responsive Hydrophilic Block CopolymersJiang, Xueguang 01 August 2010 (has links)
This dissertation presents the synthesis of stimuli-sensitive hydrophilic polymers, particularly doubly responsive hydrophilic block copolymers, by controlled radical polymerizations and the study of their solution behavior in water. By incorporating a small amount of stimuli-responsive groups into the thermosensitive block of a hydrophilic block copolymer, the lower critical solution temperature (LCST) of the thermosensitive block can be tuned by a stimulus and multiple micellization/dissociation transitions can be achieved by combining two external triggers. Chapter 1 describes the synthesis and thermosensitive properties of two new watersoluble polystyrenics with a short oligo(ethyl glycol) pendant from each repeat unit and the study of hydrophobic end group effects on cloud points of thermosensitive polystyrenics. Well-defined polymers were prepared from monomer-based initiators via nitroxide-mediated polymerization and the alkoxyamine end groups were removed by tri(n-butyl)tin hydride, yielding thermoresponsive polystyrenics with essentially no end groups. The results showed that hydrophobic end groups could significantly change the cloud points and the molecular weight dependences of cloud points of polystyrenics. Chapter 2 presents the synthesis of thermo- and light-sensitive hydrophilic block copolymers, poly(ethylene oxide)-b-poly(ethoxytri(ethylene glycol) acrylate-co-onitrobenzyl acrylate), and their responsive behavior in dilute aqueous solutions. Dynamic light scattering and fluorescence spectroscopy studies showed that these copolymers were molecularly dissolved in water at lower temperatures and self-assembled into micelles at temperatures above the LCST of the thermosensitive block. Upon UV irradiation, the oiv nitrobenzyl group was cleaved and the LCST of the thermosensitive block was increased, causing the dissociation of micelles into unimers. The resultant copolymers underwent thermo-induced reversible micellization at higher temperatures. Chapter 3 describes multiple micellization/dissociation transitions of thermo- and pH-sensitive hydrophilic block copolymers, poly(ethylene oxide)-b-poly(methoxydi(ethylene glycol) methacrylate-co-methacrylic acid), in response to temperature and pH changes. The LCST of the thermosensitive block can be reversibly tuned and precisely controlled by solution pH. Chapter 4 presents the study on multiple sol-gel-sol transitions of a 20.0 wt % aqueous solution of poly(ethylene oxide)-b-poly(ethoxytri(ethylene glycol) acrylate-co-o-nitrobenzyl acrylate) induced by temperature changes and UV irradiation. The solution underwent thermo-induced sol-gel-sol transitions. Upon UV irradiation to dissociate micelles, the gel was transformed into a free-flowing liquid, which upon heating underwent sol-gel-sol transitions again.
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Organometallic catalysis in aqueous solution : reactions and mechanisms of water-soluble molybdocenes /Breno, Kerry L., January 2004 (has links)
Thesis (Ph. D.)--University of Oregon, 2004. / Typescript. Includes vita and abstract. Includes bibliographical references (leaves 213-252). Also available for download via the World Wide Web; free to University of Oregon users.
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In vitro characterisation of food effects on in vivo performance of a heterodisperse polysaccharide-based controlled drug delivery system in gastrointestinal tractMu, Xiaohong January 2000 (has links)
No description available.
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Synthesis of cationic macromonomers by living polymerizations for comb-branched polyelectrolytes /Zeng, Faquan. January 2001 (has links)
Thesis (Ph.D.) -- McMaster University, 2001. / Includes bibliographical references. Also available via World Wide Web.
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Development and optimisation of polymeric matrices for use in biomolecular devices /Franklin, Jeffery D., January 1900 (has links)
Thesis (Ph.D.) - Carleton University, 2003. / Includes bibliographical references. Also available in electronic format on the Internet.
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