Let $\bk$ be a field of characteristic zero. A Pham-Brieskorn ring is a $\bk$-algebra of the form $B_{a_0,\dots,a_n} = \bk[X_0,\dots,X_n] / \lb X_0^{a_0} + \cdots + X_n^{a_n} \rb$, where $n \geq 2$ and $a_0, \dots, a_n$ are positive integers. A ring $B$ is rigid if the only locally nilpotent derivation $D : B \to B$ is the zero derivation. Consider the following conjecture. \begin{conjnonumber}\label{PBConjectureAbstract} Let $n \geq 2$, and let $B_{a_0, \dots, a_n} = \bk[X_0, \dots, X_n] / \langle X_0^{a_0} + \cdots + X_n^{a_n} \rangle$ be a Pham-Brieskorn ring. If $\min\{a_0, \dots,a_n \} \geq 2$ and at most one element $i$ of $\{0,\dots ,n\}$ satisfies $a_i = 2$, then $B_{a_0, \dots, a_n}$ is rigid. \end{conjnonumber} The $n = 2$ case of the Conjecture is known to be true. In this thesis, we make progress towards solving the above conjecture. Our main results are: \begin{enumerate}[\rm(1)] \item For any $n \geq 3$, in order to prove the above conjecture, it suffices to prove rigidity of $B_{a_0, \dots, a_n}$ in the cases where $\bk = \Comp$ and $\cotype(a_0, \dots, a_n) = 0$. \item For any $n \geq 2$, $X = \Proj B_{a_0, \dots, a_n}$ is a well-formed quasismooth weighted complete intersection if and only if $\cotype(a_0, \dots, a_n) = 0$. \item When $n = 3$ and $\cotype(a_0, a_1, a_2, a_3) = 0$, $B_{a_0, a_1, a_2, a_3}$ is rigid, except possibly in the cases where, up to a permutation of the $a_i$, $(a_0, a_1, a_2, a_3) \in \{(2,3,4,12), (2,3,5,30)\}$. \item We summarize the list of 3-dimensional Pham-Brieskorn rings $B_{a_0, a_1, a_2, a_3}$ for which rigidity is known. It follows in particular that if $B_{2,3,4,12}$ and $B_{2,3,5,30}$ are rigid then the $n = 3$ case of the above conjecture is true. \end{enumerate} In addition to the above, we develop techniques for proving rigidity of rings in general; prove rigidity of many Pham-Brieskorn rings whose dimension is greater than 3; give simple examples of rational projective surfaces with quotient singularities that have an ample canonical divisor and prove that the members of a certain family of singular hypersurfaces are not rational.