Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-06-03T23:35:59Z No. of bitstreams: 1 NaraCristinaFrutuosoFerreira_DISSERT.pdf: 12389020 bytes, checksum: 5a200b777caef45fa95fbc75b5af5e27 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-06-07T19:26:50Z (GMT) No. of bitstreams: 1 NaraCristinaFrutuosoFerreira_DISSERT.pdf: 12389020 bytes, checksum: 5a200b777caef45fa95fbc75b5af5e27 (MD5) / Made available in DSpace on 2016-06-07T19:26:50Z (GMT). No. of bitstreams: 1 NaraCristinaFrutuosoFerreira_DISSERT.pdf: 12389020 bytes, checksum: 5a200b777caef45fa95fbc75b5af5e27 (MD5) Previous issue date: 2014-05-05 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / O g?nero Waltheria, pertencente ? fam?lia Sterculiaceae, ? reportado como fonte prol?fica de flavonoides e alcal?ides quinol?nicos, subst?ncias de grande interesse devido ?s v?rias atividades biol?gicas associadas. Este trabalho relata o estudo fitoqu?mico in?dito do extrato etan?lico de Waltheria ferruginea, visando contribuir para o conhecimento qu?mico da esp?cie e o isolamento de subst?ncias com potencial biol?gico. Para o estudo fitoqu?mico foram usadas t?cnicas de cromatografias em s?lica gel e por exclus?o molecular em Sephadex LH-20, seguido por purifica??o por Cromatografia L?quida de Alta Efici?ncia. A elucida??o estrutural dos constituintes isolados foi realizada utilizando as t?cnicas espectrom?tricas de IV, EM, RMN 1H e 13C uni e bidimensionais e compara??o com dados reportados na literatura. Foram isoladas cinco subst?ncias, quais sejam: os flavon?ides canferol-3-O-?-(6''-cumaroil)-glicopiranos?deo (F1), quercetina-3-O-?-glicopiranos?deo (F2), ambas as mol?culas com propriedades por farmacol?gicas comprovadas, al?m do canferol-3-O- ?-glicopiranos?deo (F3), o terpeno geranil-geranila (G1) e o ?cido 12-hidroxi-octadecan?ico (A1), todas in?ditas para a esp?cie. / The Waltheria genus belonging to the Sterculiaceae family, it is reported as a prolific source of flavonoids and quinolone alkaloids, substances of great interest due to several associated biological activities. This work describes a novel phytochemical study from Waltheria ferruginea, aiming to contribute to the chemical knowledge of this specie and the isolation of substances with biological potential. For the phytochemical study were used chromatography techniques on silica gel and molecular exclusion in Sephadex LH-20.The structural elucidation of the isolated compounds was performed through spectrometric techniques 1H and 13C NMR, including uni and bidimensional pulse sequences, and comparison with data from literature. Five substances were isolated, namely: the flavonids kaempferol-3-O-?-(6''-cumaroil)-glucopyranoside (F1) and kaempferol -3 -O- ? - glucopyranoside (F2), both analyzes with pharmacological properties, the flavonol quercetin-3-O-?-glucopyranoside (F3 ) pure and in the epimeric mixture ? (F3') and (F3), the terpenegeranyl - geranyl (G1) and the 12-hydroxi-octadecanoic acid, all no previous reported in the literature.