Research can conflict with conservation when invasive techniques are used on protected animal species. We developed a decision framework including the research question, the choice of technique, and the recommended course of action following the evaluation of the risks and benefits. This evaluation includes biological risks and benefits and considerations linked to the perception of resource users. We applied this framework a posteriori to a case study, the use of biopsy sampling on St. Lawrence belugas. We monitored the biological risks and benefits over four field seasons using behavioural and physiological indices and reports on the work in progress. We evaluated the risks as "low" and the benefits as "medium". For benefits to outweigh risks, procedures to minimise risks, publication of the work, and formulation of recommendations for conservation are essential. Researchers should be prepared to discuss with stakeholders the potential conflicts between their projects and conservation.

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