The IEEE 802.15.4 standard is an interesting technology for use in Wireless Body Sensor Networks (WBSN), where entire networks of sensors are carried by humans. In many environments the sensor nodes experience external interference for example, when the WBSN is operated in the 2.4 GHz ISM band and the human moves in a densely populated city, it will likely experience WiFi interference, with a quickly changing ``interference landscape''. In this thesis we propose Adaptive Resource Allocation schemes, to be carried out by the WBSN, which provided noticeable performance gains in such environments. We investigate a range of adaptation schemes and assess their performance both through simulations and experimentally.