An important aspect in the process of architectural design is the testing of solution alternatives in order to evaluate them on their appropriateness within the context of the design problem. Computational Fluid Dynamics (CFD) analysis is one of the approaches that have gained popularity in the testing of architectural design solutions especially for purposes of evaluating the performance of natural ventilation strategies in buildings. Natural ventilation strategies can reduce the energy consumption in buildings while ensuring the good health and wellbeing of the occupants. In order for natural ventilation strategies to perform as intended, a number of factors interact and these factors must be carefully analysed. CFD simulations provide an affordable platform for such analyses to be undertaken. Traditionally, these simulations have largely followed the direction of Best Practice Guidelines (BPGs) for quality control. These guidelines are built around certain simplifications due to the high computational cost of CFD modelling. However, while the computational cost has increasingly fallen and is predicted to continue to drop, the BPGs have largely remained without significant updates. The need to develop a CFD simulation framework that leverages the contemporary and anticipates the future computational cost and capacity can, therefore, not be overemphasised. When conducting CFD simulations during the process of architectural design, the variability of the wind flow field including the wind direction and its velocity constitute an important input parameter. Presently, however, in many simulations, the wind direction is largely used in a steady state manner. It is assumed that the direction of flow downwind of a meteorological station remains constant. This assumption may potentially compromise the integrity of CFD modelling as in reality, the wind flow field is bound to be dynamic from place to place. In order to improve the accuracy of the CFD simulations for architectural design, it is therefore necessary to adequately account for this variability. This study was a two-pronged investigation with the ultimate objective of improving the accuracy of the CFD simulations that are used in the architectural design process, particularly for the design and analysis of natural ventilation strategies. Firstly, a framework for integrated meso-scale and building scale CFD simulations was developed. Secondly, the newly developed framework was then implemented by deploying it to study the variability of the wind flow field between a reference meteorological station, the Virginia Tech Airport, and a selected localized building scale site on the Virginia Tech campus. The findings confirmed that the wind flow field varies from place to place and showed that the newly developed framework was able to capture this variation, ultimately, generating a wind flow field characterization representative of the conditions prevalent at the localized building site. This framework can be particularly useful when undertaking de-coupled CFD simulations to design and analyse natural ventilation strategies in the building design process. / Doctor of Philosophy / The use of natural ventilation strategies in building design has been identified as one viable pathway toward minimizing energy consumption in buildings. Natural ventilation can also reduce the prevalence of the Sick Building Syndrome (SBS) and enhance the productivity of building occupants. This research study sought to develop a framework that can improve the usage of Computational Fluid Dynamics (CFD) analyses in the architectural design process for purposes of enhancing the efficiency of natural ventilation strategies in buildings. CFD is a branch of computational physics that studies the behaviour of fluids as they move from one point to another. The usage of CFD analyses in architectural design requires the input of wind environment data such as direction and velocity. Presently, this data is obtained from a weather station and there is an assumption that this data remains the same even for a building site located at a considerable distance away from the weather station. This potentially compromises the accuracy of the CFD analyses as studies have shown that due to a number of factors such the urban built form, vegetation, terrain and others, the wind environment is bound to vary from one point to another. This study sought to develop a framework that quantifies this variation and provides a way for translating the wind data obtained from a weather station to data that more accurately characterizes a local building site. With this accurate site wind data, the CFD analyses can then provide more meaningful insights into the use of natural ventilation in the process of architectural design. This newly developed framework was deployed on a study site at Virginia Tech. The findings showed that the framework was able to demonstrate that the wind flow field varies from one place to another and it also provided a way to capture this variation, ultimately, generating a wind flow field characterization that was more representative of the local conditions.