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This dissertation is particularly focused on a novel approach of a wirelessly powered neuromodulation system for chronic patients. The inductively coupled transmitter (TX) and receiver (RX) coils are designed through optimization to achieve maximum efficiency. A power management unit (PMU) consisting of a voltage rectifier, voltage regulator along with a stimulation circuitry is also designed to provide pulse stimulation to genetically modified neurons. For continuous health monitoring purposes, the response from the brain due to stimulation needs to be recorded and transmitted wirelessly outside the brain for analysis. A low-power high-data duty-cycled impulse-radio ultra-wideband (IR-UWB) transmitter is designed and implemented using the standard CMOS process. Another focus of this dissertation is the design of a reverse electrowetting-on-dielectric (REWOD) based energy harvesting circuit for wearable sensor applications which is capable of generating a very low-frequency signal from motion activity such a walking, running, jogging, etc. A commercial off-the-shelf (COTS) based and on-chip based energy harvesting circuit is designed for very low-frequency signals. The experimental results show promising progress towards the advancement in the wirelessly powered neuromodulation system and building the self-powered wearable sensor.