This thesis undertakes an in-depth examination of the power of human rights advocacy in combating women's vulnerability to HIV/AIDS. Focusing on sub-Saharan Africa, the thesis explores the gender discrimination that lies at the core of women's susceptibility to the virus. Culturally-imposed social roles are depicted as the fundamental cause of the violation of women's human rights, including their right to health. The objective of the thesis is to analyze the potential of using a human rights approach to address this issue. It adopts the assumption that "the mobilization of shame" triggered by civil society's actors can alter states' human rights practices. Looking at a specific type of actors, namely the transnational advocacy networks, the thesis concludes that "the human rights approach to HIV/AIDS" can be an efficient and effective strategy to pressurize governments to implement their international human rights obligations.