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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

The importance of muscle mechanics during movement: investigating power production and dynamic stability using a closed-loop system

Sundar, Kartik 02 March 2009 (has links)
Animals effectively move and negotiate a variety of environments exemplifying the neuromuscular system's ability to produce complex coordinated movements. Our central thesis is that the nonlinear dynamical properties of muscle play a critical role in power production and stability during such movements. We have developed a closed-loop system that couples an isolated muscle to a physical or computational load, facilitating the study of the interactions between intrinsic muscle properties and external forces. We used this system to determine how elastic elements in the frog semimembranosus can improve power production during a jumping task and how the contractile element automatically manages energy to maintain a stable bouncing gait. Our results reveal that, during ballistic movements (e.g. jumping), series elastic elements stretch and shorten to temporally concentrate energy transfer from the contractile element to the body, amplifying power production. We measured peak instantaneous power greater than twice the maximum power the contractile element could produce alone. Our results show how, during a bouncing gait, the contractile and elastic elements autonomously interact to produce, dissipate, and recycle energy and to maintain dynamic stability without sensory feedback. Our data suggest that muscles can recover over 75% of the kinematic energy from one step and apply it to the next. These results demonstrate the effects and importance of intrinsic muscle properties during movements. Ultimately, this research can guide the development of biomimetic robotic and prosthetic technologies capable of life-like mobility.
2

Effect of high-fat diet on isometric, concentric and eccentric contractile performance of skeletal muscle isolated from female CD-1 mice

Tallis, J., James, Rob S., Eyre, E.L.J., Shelley, S.P., Hill, C., Renshaw, D., Hurst, J. 25 July 2024 (has links)
Yes / Despite evidence inferring muscle and contractile mode-specific effects of high-fat diet (HFD), no study has yet considered the impact of HFD directly on eccentric muscle function. The present work uniquely examined the effect of 20-week HFD on the isometric, concentric and eccentric muscle function of isolated mouse soleus (SOL) and extensor digitorum longus (EDL) muscles. CD-1 female mice were randomly split into a control (n = 16) or HFD (n = 17) group and for 20 weeks consumed standard lab chow or HFD. Following this period, SOL and EDL muscles were isolated and assessments of maximal isometric force and concentric work loop (WL) power were performed. Each muscle was then subjected to either multiple concentric or eccentric WL activations. Post-fatigue recovery, as an indicator of incurred damage, was measured via assessment of concentric WL power. In the EDL, absolute concentric power and concentric power normalised to muscle mass were reduced in the HFD group (P < 0.038). HFD resulted in faster concentric fatigue and reduced eccentric activity-induced muscle damage (P < 0.05). For the SOL, maximal isometric force was increased, and maximal eccentric power normalised to muscle mass and concentric fatigue were reduced in the HFD group (P < 0.05). HFD effects on eccentric muscle function are muscle-specific and have little relationship with changes in isometric or concentric function. HFD has the potential to negatively affect the intrinsic concentric and eccentric power-producing capacity of skeletal muscle, but a lack of a within-muscle uniform response indicates disparate mechanisms of action which require further investigation.
3

High-fat diet effects on contractile performance of isolated mouse soleus and extensor digitorum longus when supplemented with high dose vitamin D

Shelley, S.P., James, Rob S., Eustace, S.J., Eyre, E.L.J., Tallis, J. 05 January 2024 (has links)
Yes / Evidence suggests vitamin D3 (VD) supplementation can reduce accumulation of adipose tissue and inflammation and promote myogenesis in obese individuals, and thus could mitigate obesity-induced reductions in skeletal muscle (SkM) contractility. However, this is yet to be directly investigated. This study, using the work-loop technique, examined effects of VD (cholecalciferol) supplementation on isolated SkM contractility. Female mice (n = 37) consumed standard low-fat diet (SLD) or high-fat diet (HFD), with or without VD (20,000 IU/kg-1 ) for 12 weeks. Soleus and EDL (n = 8-10 per muscle per group) were isolated and absolute and normalized (to muscle size and body mass) isometric force and power output (PO) were measured, and fatigue resistance determined. Absolute and normalized isometric force and PO of soleus were unaffected by diet (P > 0.087). However, PO normalized to body mass was reduced in HFD groups (P  0.588). HFD reduced EDL isometric stress (P = 0.048) and absolute and normalized PO (P  0.493). Cumulative work during fatiguing contractions was lower in HFD groups (P  0.060). This study uniquely demonstrated that high-dose VD had limited effects on SkM contractility and did not offset demonstrated adverse effects of HFD. However, small and moderate effect sizes suggest improvement in EDL muscle performance and animal morphology in HFD VD groups. Given effect sizes observed, coupled with proposed inverted U-shaped dose-effect curve, future investigations are needed to determine dose/duration specific responses to VD, which may culminate in improved function of HFD SkM. NEW FINDINGS: What is the central question of this study? Can vitamin D supplementation alleviate detrimental effects of high-fat diet (HFD) consumption on contractile performance of isolated skeletal muscles? What is the main finding and its importance? The present study is the first to examine the synergistic effects of HFD consumption and vitamin D supplementation on the contractile performance of isolated skeletal muscle. These findings suggest high dose vitamin D has limited effects on force, power or fatigue resistance of isolated mouse soleus and extensor digitorum longus.

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