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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Role of membrane fusion protein Ykt6 in regulating epithelial cell-cell and cell-matrix adhesions.Joshi, Supriya 01 May 2014 (has links)
Intercellular junctions and cell-matrix adhesions play important roles in the maintenance of epithelial integrity. Assembly and remodeling of the plasma membrane complexes are regulated by membrane trafficking and fusion. This thesis is aimed to elucidate the roles of an important membrane fusion protein, Ykt6, in the regulation of epithelial cell adhesion and migration. For the first time, we show that Ykt6 is essential for assembly of adherens junctions and tight junctions in human prostate epithelial cells. We also observed that Ykt6 negatively regulates both collective epithelial cell migration and cell invasion into Matrigel. The effects of YKT6 on epithelial junctions involves expressional regulation of key junctional proteins, E-cadherin and claudin-4, whereas its effects on cell motility can be explained by antagonizing functions of junctional adhesion molecule-A. Overall, this study identifies YKT6 as a novel regulator of epithelial cell adhesions and motility.
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Charakterisierung von SNARE-Proteinen in der Hefe Saccharomyces cerevisiae / Characterization of SNARE proteins in the yeast Saccharomyces cerevisiaeDilcher, Meik 30 January 2003 (has links)
No description available.
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