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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Primary Care in the Digital Age: is mHealth the answer? : A Quantitative Study Assessing Factors Influencing Young Elderly Swedes' Attitudes Towards mHealth for Primary Healthcare

Göransson, Sanna, Hajdu, Nelli January 2023 (has links)
The combination of declining birth rates and an aging Swedish population presents challenges for the government in terms of accommodating and providing for the needs of a larger and older population. This demographic shift will exert significant pressure on the public sector, particularly the healthcare system. The potential of digitized healthcare to address the challenges posed by the aging population is significant, and mHealth technologies may be part of the solution to addressing these challenges. This study seeks to examine and quantify the key factors that influence the attitudes of young elderly (ages 45-60) individuals in Sweden towards the adoption of mHealth technologies. Specifically, the research aims to assess the factors that impact willingness to adopt technologies for managing primary healthcare needs. By identifying and measuring these influencing factors, the study strives to contribute to a better understanding of the drivers behind the adoption of mHealth solutions among this demographic. The study employs a single-method research design with a deductive empirical approach, using an online survey to collect quantitative data through a snowballing sampling technique. The study introduced three new variables (General Technology Experience, Healthcare Technology Experience, and Security and Privacy) and three new moderators (Being a Parent, Highest Level of Education, and Frequency of Primary Care Visits) to the widely recognized UTAUT framework. The results were analyzed using Excel and SPSS to identify patterns, relationships, and trends that emerged from the empirical data. Via analysis of the collected survey data, it was found that Performance Expectancy strongly influences the adoption of mHealth technologies among young elderly Swedes. Social Influence and Security and Privacy have minimal impact on adoption decisions. Security and Privacy show a negative correlation to willingness to adopt, indicating mistrust. Higher education levels are associated with digital literacy and belief in technology's job performance benefits. Lower education levels correlate with higher social influence. Individuals visiting primary care 2-3 times a year exhibit higher technology experience and social influence.
2

Macrófagos M1 e M2 e sua relação com a angiogênese em carcinomas espinocelulares orais afetando pacientes jovens e idosos / M1 and M2 macrophages and their relation with angiogenesis in oral squamous cell carcinoma affecting young and elderly patients

Teixeira, Lucas Ribeiro 15 March 2019 (has links)
O carcinoma espinocelular oral (CECO) corresponde a aproximadamente 95% das neoplasias malignas que acometem a cavidade oral. Os fatores de risco clássicos incluem o tabagismo e etilismo; no entanto, as disfunções do sistema imune em decorrência do envelhecimento (imunossenescência) na patogênese do CECO são muito pouco estudados. Análises comparativas vêm sendo feitas para melhor caracterização do perfil de pacientes jovens e idosos acometidos pelo CECO, o qual permanece ainda controverso. Vários estudos têm mostrado que os macrófagos associados ao tumor (MATs) no CECO de pacientes idosos exibem um fenótipo M2 (pró-tumoral), com propriedades moduladoras do estroma vascular, promovendo a angiogênese. No entanto, considerando a imunossenescência, não se sabe o perfil de MATs e seus efeitos na angiogenese no CECO afetando pacientes jovens. Assim, este estudo analisou por meio da técnica imunoistoquímica, a frequência e localização de MATs em correlação com a angiogênese, no CECO, afetando pacientes jovens e idosos. Cinquenta e sete biópsias de CECO divididos em 3 grupos (I: <40 anos [n=17]; II: 40-65 anos [n=20]; III: >65 anos [n=20]) foram selecionados para compor o estudo, sendo classificados morfologicamente seguindo às recomendações da OMS (2017). Os grupos I, II e III foram comparados quanto à imunoexpressão de CD68 e CD163 para análise de MATs e de CD34 (vasos sanguíneos) e D2-40 (vasos linfáticos) para avaliação da densidade microvascular (DMV), área microvascular (AMV) e área vascular total (AVT). A análise imunoistoquímica evidenciou similar expressão de CD68 e CD163 nos três grupos (p>0,05). A avaliação da DMV, AMV e AVT sanguínea e linfática também exibiu padrões similares, com predominância significativa (p<0.05) de vasos sanguíneos, nos três grupos analisados. Não houve correlação significativa quando avaliados marcadores macrofágicos e angiogênicos. Nossos resultados mostram um similar perfil de MATs e angiogênese quando comparados os três grupos estudados, sugerindo participação de mecanismos moleculares do microambiente tumoral na manutenção da predominância de macrófagos M2 e vasos sanguíneos no CECO afetando pacientes jovens e idosos / Oral squamous cell carcinoma (OSCC) corresponds to approximately 95% of all cases of oral cavity malignancies. The classic risk factors include smoking and alcoholism; however, immune system dysfunctions due to aging (immunoscencence) in OSCC pathogenesis are poorly studied. Comparative analyzes have been made to better characterize the profile of young and old patients affected by the OSCC, which remains controversial. Several studies have shown that tumor-associated macrophages (TAMs) in OSCC of elderly patients exhibit a pro-tumoral M2 phenotype, with vascular stroma modulating properties, promoting angiogenesis. However, considering immunoscencence, the profile of TAMs and their effects on angiogenesis in OSCC affecting young patients is unknown. Thus, this study analyzed by immunohistochemical technique, the frequency and location of TAMs in correlation with angiogenesis in OSCC affecting young and elderly patients. Fiftyseven biopsies were divided into three groups (I: <40 years [n=17]; II: 40-65 years [n=20]; III: > 65 years [n=20]) and selected to compose this study, being classified morphologically following WHO (2017) recommendations. Groups I, II and III were compared for immunoexpression of CD68 and CD163 for analysis of TAMs, and CD34 (blood vessels) and D2-40 (lymphatic vessels) for evaluation of microvessel density (MVD), microvascular area (MVA) and total vascular area (TVA). Immunohistochemical analysis showed similar expression of CD68 and CD163 in the three groups (p>0.05). The evaluation of blood and lymphatic MVD, MVA and TVA also showed similar patterns, with a significant predominance (p<0.05) of blood vessels in the three groups analyzed. There was no significant correlation when evaluating macrophage and angiogenic markers. Our results show a similar profile of TAMs and angiogenesis when compared to the three groups studied, suggesting participation of molecular mechanisms of the tumor microenvironment in the maintenance of M2-polarized macrophages and blood vessels in OSCC affecting young and elderly patients

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