This manuscript consists of two papers that formulate novel methodologies pertaining to time series analysis in the state-space framework. In Chapter 1, we introduce an innovative time series forecasting procedure that relies on model-based clustering and model averaging. The clustering algorithm employs a state-space model comprised of three latent structures: a long-term trend component; a seasonal component, to capture recurring global patterns; and an anomaly component, to reflect local perturbations. A two-step clustering algorithm is applied to identify series that are both globally and locally correlated, based on the corresponding smoothed latent structures. For each series in a particular cluster, a set of forecasting models is fit, using covariate series from the same cluster. To fully utilize the cluster information and to improve forecasting for a series of interest, multi-model averaging is employed. We illustrate the proposed technique in an application that involves a collection of monthly disease incidence series. In Chapter 2, to effectively characterize a count time series that arises from a zero-inflated binomial (ZIB) distribution, we propose two classes of statistical models: a class of observation-driven ZIB (ODZIB) models, and a class of parameter-driven ZIB (PDZIB) models. The ODZIB model is formulated in the partial likelihood framework. Common iterative algorithms (Newton-Raphson, Fisher Scoring, and Expectation Maximization) can be used to obtain the maximum partial likelihood estimators (MPLEs). The PDZIB model is formulated in the state-space framework. For parameter estimation, we devise a Monte Carlo Expectation Maximization (MCEM) algorithm, using particle methods to approximate the intractable conditional expectations in the E-step of the algorithm. We investigate the efficacy of the proposed methodology in a simulation study, and illustrate its utility in a practical application pertaining to disease coding.