Despite a substantial expanse of literature addressing male sexual offending, the phenomenon of female sexual offending has only recently garnered empirical attention. While research remains nascent in nature, considerable advances have been made in the study of demographics, criminal characteristics, and typologies of female sexual offenders (FSOs). Similarities and differences between male and female sexual offenders have been the source of much speculation; however, hypotheses arising from this speculation have rarely been subjected to empirical scrutiny. Similarly, there has been limited examination of intra-group differences among FSOs. While myriad actuarial assessments have been developed for use with male offenders, similar measures for female offenders are practically non-existent. One notable exception is the Multiphasic Sex Inventory II (MSI II), an instrument with both male and female forms. The present study analyzed, compared, and contrasted the MSI II protocols of 300 male and female adult sex offenders.