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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Spelling suggestions: "subject:"adrenergic bioantagonists (pharmacology)"" "subject:"adrenergic bmpantagonists (pharmacology)""

1

Relaxation of Isolated Human Myometrial Muscle by beta2-Adrenergic Receptors but Not beta1-Adrenergic Receptors

Liu, Ying L., Nwosu, Uchenna C., Rice, P. J. 01 October 1998 (has links)
OBJECTIVE: Human myometrium contains both beta1-adrenergic and beta2-adrenergic receptors. This study was designed to assess the importance of each beta-adrenergic receptor subtype in relaxation of human myometrial muscle strips. STUDY DESIGN: Radioligand binding studies were used to establish the presence of each beta-adrenergic receptor subtype, whereas highly selective beta1-antagonists and beta2-antagonists were used to assess the contribution of beta-adrenergic receptor subtypes to myometrial relaxation after exposure to (-)-isoproterenol. RESULTS: Membranes prepared from myometrium contained 82% +/- 4% beta2-adrenergic receptors. After contraction produced by exposure to potassium chloride (35 mmol/L), isoproterenol produced relaxation with half maximal effect at 0.02 micromol/L and a maximal relaxation of 52% +/- 3%. Beta1-antagonist CGP-20712A had no significant effect, whereas beta2-antagonist ICI-118551 produced a characteristic rightward shift of the isoproterenol concentration-relaxation relationship. CONCLUSIONS: Although both beta1-adrenergic receptors and beta2-adrenergic receptors are present in human myometrial tissue at term, relaxation by nonselective beta-agonist isoproterenol is mediated exclusively by beta2-adrenergic receptors.
adrenergic beta-agonists (pharmacology)
female
humans
imidazoles (pharmacology)
in vitro techniques
isoproterenol (pharmacology)
muscle relaxation (physiology)
myometrium (drug effects
physiology)
potassium chloride (pharmacology)
propanolamines (pharmacology)
radioligand assay
receptors
adrenergic
beta-1 (physiology)
receptors
adrenergic
beta-2 (physiology)
Biostatistics and Epidemiology

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