<p> The absence of a protecting magnetic field, such as the dipole magnetic field around Earth, makes the interaction of solar wind with unmagnetized objects particularly interesting. Long-term evolution of the object&rsquo;s surface and atmosphere is closely tied to its interaction with the outer space environment. The ionospheric plasma layer around unmagnetized objects acts as an electrically conducting transition layer between lower atmospheric layers and outer space. This study considers two distinct types of unmagnetized objects: Titan and comet 67P/Churyumov-Gerasimenko (67P/CG). For many years, Titan has been a key target of the National Aeronautics and Space Administration (NASA) Cassini mission investigations; and the European Space Agency (ESA) Rosetta spacecraft explored comet 67P/CG for more than two years. </p><p> Ionospheric composition and primary ion production rate profiles for Titan are modeled for various solar activity conditions. Photoionization is the main source of ion production on the dayside; on the nightside, electron-impact ionization is the main ionization source. This dissertation uses model results and in-situ measurements by the Ion and Neutral Mass Spectrometer (INMS) and the Langmuir Probe (LP) onboard the Cassini spacecraft to show that while the solar activity cycle impacts the primary ion species significantly, there is little effect on heavy ion species. Solar cycle modulates the Titan&rsquo;s ionospheric chemistry. The solar cycle effects of on each ion species are quantified n this work. In some cases the solar zenith angle significantly overshadows the solar cycle effects. How each individual ion reacts to changes in solar activity and solar zenith angle is discussed in details. A method to disentangle these effects in ion densities is introduced. </p><p> At comet 67P/CG, the fast-moving solar wind impacts the neutral coma. Two populations of electrons are recognizable in the cometary plasma. These are the hot suprathermal electrons, created by photoionization or electron-impact ionization, and the cold/thermal electrons. Even though photoionization is the dominant source of ion production, electron-impact ionization can be as high as the photoionization for certain solar events. At 3 AU, electron energy spectra from in-situ measurements of the Ion and Electron Sensor (IES) instrument exhibit enhancement of electron fluxes at particular energies. Model-data comparisons show that the flux of electrons is higher than the typical solar wind and pure photoionization fluxes. The probable cause of this enhancement is the ambipolar electric field and/or plasma compression. </p><p> This research also discusses formation of a new boundary layer around the comet near perihelion, similar to the diamagnetic cavity at comet 1P/Halley. At each crossing event to the diamagnetic cavity region, flux of suprathermal electrons with energies between 40 to 250 eV drops. The lower flux of solar wind suprathermal electrons in that energy range can cause this flux drop. </p><p>

<p> The molecular mechanisms governing gamma-globin expression in a subset of fetal hemoglobin (alpha₂:gamma₂; HbF) expressing red blood cells (F-cells) and the mechanisms underlying the variability of response to hydroxyurea induced gamma-globin expression in the treatment of sickle cell disease are not completely understood. To explore molecular differences in these conditions, a serum-free <i>in vitro</i> culture system suitable for large scale production of erythroblasts derived from primary human hematopoietic progenitors is optimized. The culture system recapitulates steady-state adult erythropoiesis and can support erythroid differentiation with the addition of cytotoxic hydroxyurea. Using this system, intra-person clonal populations of erythroblasts derived from bone marrow common myeloid progenitors were evaluated for molecular factors associated with gamma-globin expression. Data demonstrate that the level of fetal hemoglobin produced in F-cells negatively correlates with expression of BCL11A, KLF1 and TALL With the addition of hydroxyurea, successful induction of gamma-globin includes a further reduction in BCL11 A, KLF1 and TALI expression along with a decrease in SOX6 expression. These data suggests that expression changes in this transcription factor network modulate gamma-globin expression in F-cells during steady state erythropoiesis and after induction with hydroxyurea.</p>

<p> Uncertainty in the emission estimates is one the main reasons for shortcomings in the Chemistry Transport Models (CTMs) which can reduce the confidence level of impact assessment of anthropogenic activities on air quality and climate. This dissertation focuses on understating the uncertainties within the CTMs and reducing these uncertainties by improving emission estimates </p><p> The first part of this dissertation focuses on reducing the uncertainties around the emission estimates from oil and Natural Gas (NG) operations by using various observations and high-resolution CTMs. To achieve this goal, we used Weather Research and Forecasting with Chemistry (WRF-Chem) model in conjunction with extensive measurements from two major field campaigns in Colorado. Ethane was used as the indicator of oil and NG emissions to explore the sensitivity of ethane to different physical parametrizations and simulation set-ups in the WRF-Chem model using the U.S. EPA National Emission Inventory (NEI-2011). The sensitivity analysis shows up to 57.3% variability in the modeled ethane normalized mean bias (NMB) across the simulations, which highlights the important role of model configurations on the model performance. </p><p> Comparison between airborne measurements and the sensitivity simulations shows a model-measurement bias of ethane up to -15ppb (NMB of -80%) in regions close to oil and NG activities. Under-prediction of ethane concentration in all sensitivity runs suggests an actual under-estimation of the oil and NG emissions in the NEI-2011 in Colorado. To reduce the error in the emission inventory, we developed a three-dimensional variational inversion technique. Through this method, optimal scaling factors up to 6 for ethane emission rates were calculated. Overall, the inversion method estimated between 11% to 15% higher ethane emission rates in the Denver-Julesburg basin compared to the NEI-201. This method can be extended to constrain oil and NG emissions in other regions in the US using the available measurement datasets. </p><p> The second part of the dissertation discusses the University of Iowa high-resolution chemical weather forecast framework using WRF-Chem designed for the Lake Michigan Ozone Study (LMOS-2017). LMOS field campaign took place during summer 2017 to address high ozone episodes in coastal communities surrounding Lake Michigan. The model performance for clouds, on-shore flows, and surface and aircraft sampled ozone and NOx concentrations found that the model successfully captured much of the observed synoptic variability of onshore flows. Selection of High-Resolution Rapid Refresh (HRRR) model as initial and boundary condition, and the Noah land surface model, significantly improved comparison of meteorology variables to both ground-based and aircraft data. Model consistently underestimated the daily maximum concentration of ozone. Emission sensitivity analysis suggests that increase in Hydrocarbon (HC). Variational inversion method and measurements by GeoTAS and TROPOMI instruments and airborne and ground-based measurements can be used to constrain NOx emissions in the region.</p><p>

The upper atmosphere, a region above ~85 km called the ionosphere and thermosphere, has been studied extensively for over one hundred years. Measurements were often considered in isolation, but today, advances in technology and ground-based distributed arrays have allowed concurrent multi-instruments measurements. In this dissertation, I combine measurements from all-sky imagers (ASIs), coherent scatter radars, incoherent scatter radars (ISRs), and Fabry-Perot interferometers (FPIs). I focus on two phenomena, the midnight temperature maximum (MTM) and equatorial spread F (ESF), using observations from equatorial to mid-latitudes. The spatial characteristics of these phenomena are not fully understood. I combine observations at various latitudes and longitudes to extend MTM detection to mid-latitudes. I present the first simultaneous detections of the MTM at multiple altitudes and latitudes over North America and the first observations below the F-region peak using the Millstone Hill Observatory ISR in a south pointing, low-elevation mode. The MTM can also be observed with an ASI and I present concurrent measurements of the MTM with an ASI and ISR. The Whole Atmosphere Model, a global circulation model, was found to be consistent with these observations. This further verifies that the MTM is partially created by lower atmospheric tides, demonstrating coupling between the lower and upper atmosphere. In addition to the MTM, I investigate different aspects of ESF using ASIs concurrently with other instruments. I compare various scale sizes (sub-meter to kilometers) using coherent scatter radar and an ASI and conclude that the lower hybrid drift instability causes radar echoes to occur preferentially on the western wall of large-scale depletions. The source of day-to-day variability in ESF is not fully known but I show that one driver may be large-scale wave structures (~400 km) that modulate the development of ESF. Finally, I compare concurrent observations of ESF plasma depletions with ASIs at magnetically-conjugate foot points and show how the magnitude and structure of the Earth’s magnetic field is responsible for differences in the morphology and velocity of these depletions. In summary, I have used multi-instrument observations of ESF and the MTM to provide a deeper understanding of the dynamics of the upper atmosphere.

No description available.

<p> Every year approximately 17,000 adolescents ages 15-19 become pregnant in New York City. Most of these pregnancies are unintended and only a small percent of adolescents use effective contraception, with wide disparities by race/ethnicity and poverty level. While many studies have identified factors associated with contraceptive use, most research has focused on individual level factors, with little attention to the contribution of the school environment to sexual risk behavior and contraceptive use. This study investigates the effect of school-level factors on contraceptive use among adolescents in NYC public high schools before and after controlling for individual-level factors, and whether this effect varies with race/ethnicity. Using a cross-sectional design, the NYC Youth Risk Behavior Survey (YRBS) individual-level datasets for 2007, 2009 and 2011 were linked to a school-level dataset. Variables were selected based on empirical findings on factors associated with sexual behaviors, including contraceptive use, by adolescents. The analytic sample included all YRBS respondents aged 14 or older who reported having sexual intercourse in the past three months and had complete responses to the YRBS questions on contraceptive use at last sex (N=8,054). The chi square test of significance was used to evaluate significant associations between independent variables and contraceptive use in bivariate analyses; variables with a p value &lt; 0.1 were included in the multivariable analyses. Binary and multinomial logistic regression analyses were conducted to estimate the strength of the associations of school-level factors with contraceptive use among sexually active adolescents. Findings included that use of any contraception and/or hormonal contraception at last sexual intercourse was associated with attending schools with a higher six-year graduation rate, higher percent of students strongly agreeing they were safe in their classrooms, higher percent of teachers at the school for over two years, and having a School-Based Health Center (SBHC) in the building. No known study has examined the contribution of school-level effects to contraceptive use in a dataset linking YRBS and school-level datasets. Implications of research findings are that schools providing a supportive, engaging and safe environment can protect students from sexual risk behaviors and increase contraceptive use among sexually active adolescents. &#8195; </p>

The ionospheres of Venus and Mars are important components of the planet-space boundary that play a major role in atmospheric escape processes. Characterization of these regions reveals the physical processes that control them and provides a foundation for more detailed studies of chemistry, dynamics, and energetics. At both planets the ionospheres contain two layers: the main layer, which is formed by photoionization from extreme ultraviolet radiation (EUV, λ<120 nm), and the lower layer, which is formed by photoionization from soft X-rays (SXRs, λ<10 nm) and subsequent electron impact ionization. In this dissertation I investigate how the solar EUV and SXR irradiance controls these layers at Venus and Mars. First, I develop an empirical model of the ultraviolet (UV, λ<190 nm) solar spectrum as a function of F10.7, which is a commonly used proxy of the UV irradiance. I derive power-law relationships between F10.7 and the ionizing irradiance for five neutral species and show that the relationships are nonlinear. These relationships can be used to estimate the EUV irradiance when no solar spectrum measurements are available. Second, I show that the peak electron densities in the ionospheres of Venus and Mars are proportional to the square-root of the ionizing irradiance, which is in contrast to previous studies that have used F10.7 as their representation of the UV irradiance. This finding ameliorates a discrepancy between theory and observations and is in agreement with the prediction that dissociative recombination is the main ion loss mechanism near the ionospheric peaks at Venus and Mars. Third, using a numerical model and electron density profiles from Venus Express, I examine the behavior of the peak altitude, peak density, and morphology of the lower layer at Venus. I show that the peak altitudes and densities in the lower and main layers vary similarly with solar zenith angle (SZA). This implies that neutral and electron thermal gradients at these altitudes vary little with SZA. I also show that, compared to the main layer, the lower layer morphology and peak density varies more over the solar cycle due to the hardening of the solar spectrum.

No description available.

Look up! Travelling over your head in the air are waves. They are present all the time in the atmosphere all over the Earth. Now imagine throwing a small rock in a pond and watching the ripples spread out around it. The same thing happens in the atmosphere except the rock is a thunderstorm, the wind blowing over a mountain, or another disturbance. As the wave (known as a gravity wave) travels upwards the thinning air allows the wave to grow larger and larger. Eventually the gravity wave gets too large – and like waves on the beach – it crashes causing whitewater or turbulence. If you are in the shallow water when the ocean wave crashes or breaks, you would feel the energy and momentum from the wave as it pushes or even knocks you over. In the atmosphere, when waves break they transfer their energy and momentum to the background wind changing its speed and even direction. This affects the circulation of the atmosphere. These atmospheric waves are not generally visible to the naked eye but by using special instruments we can observe their effects on the wind, temperature, density, and pressure of the atmosphere. This dissertation discusses the use of a specialized camera to study gravity waves as they travel through layers of the atmosphere 50 miles above the Andes Mountains and change the temperature. First, we introduce the layers of the atmosphere, the techniques used for observing these waves, and the mathematical theory and properties of these gravity waves. We then discuss the camera, its properties, and its unique feature of acquiring temperatures in the middle layer of the atmosphere. We introduce the observatory high in the Andes Mountains and why it was selected. We will look at the nightly fluctuations (or willy-nillyness) and long-term trends from August 2009 until December 2017. We compare measurements from the camera with similar measurements obtained from a satellite taken at the same altitude and measurements from the same camera when it was used at a different location, over Hawaii. Next, we measure the amount of change in the temperature and compare it to a nearby location on the other side of the Andes Mountains. Finally, we look for a specific type of gravity wave caused by wind blowing over the mountains called a mountain wave and perform statistics of those observed events over a period of six years. By understanding the changes in atmospheric properties caused by gravity waves we can learn more about their possible sources. By knowing their sources, we can better understand how much energy is being transported in the atmosphere, which in turn helps with better weather and climate models. Even now –all of this is going on over your head!

In this thesis, two dimensional, incompressible, viscous flow past bluff bodies and a bridge section, in which strong vortex shedding and unsteady attribute of flow are generally found, is simulated by means of random vortex method. The algorithm and method are described in detail. The validation and applicability of the developed numerical implementation to general wind engineering problems is illustrated by solving a number of classical problems, such as flow past circular and square cylinders. An application of the numerical implementation in the area of computational wind engineering is performed by analyzing a bridge deck section. Moreover, all results are compared with experimental and numerical studies in literature.