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This thesis has developed a brief history of purchasing education as it relates to the National Association of Purchasing Management (N.A.P.M.). Specific attention has been given to the curricula for purchasing management developed by the N.A.P.M. and the University of Wisconsin Bureau of Business Research.The study also described the educational background of a sample of purchasing practitioners, members of the N.A.P.M. in Central Indiana. The educational backgrounds were explored in terms of both level of education in years and content of education as related to a list of specific courses from the N.A.P.M. and University of Wisconsin Curricula.Likewise, the study has explored the educational needs of the sample by determining the specific courses that are and that would be most valuable to the practitioner in his present purchasing position. In addition, the thesis has determined the job position levels of the sample, based on job titles. The educational background of the sample within each job position level was determined. The educational needs at each job position level were also described.

Cyclosporine A (CsA) is a widely used immunosuppressive drug which has novel, clinically beneficial effects on the immune system. Substantial evidence indicates that CsA acts preferentially by impairing T cell lymphokine production, but there is some evidence that CsA may also affect B cells and other antigen presenting cells directly. Using an in vitro antibody response to sheep red blood cells, we have examined the effect CsA has on different populations of mouse lymphocytes. CsA appears to have a direct inhibitory effect on highly purified B cells from naive animals in a dose dependent manner at physiologically achievable levels in vitro. Even antigen stimulated B cells were found to be sensitive to the late addition of CsA when the drug was added simultaneously with lymphokine. B cells and T cells briefly pulsed with CsA do not recover to produce antibody when CsA is removed. Indeed, B cells from naive animals treated in vivo with CsA and stimulated in vitro with lymphokine and SRBC to produce antibody are profoundly inhibited from producing PFC despite the absence of CsA in culture. These findings suggest that CsA has direct irreversible, fast acting inhibitory effects on B lymphocytes aside from or in addition to its effects on T cells. / Department of Biology

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