Thesis (Ph. D.)--Lehigh University, 2003. / Includes bibliographical references and vita.

Thesis (Ph. D.)--University of Texas at Austin, 2000. / Vita. Includes bibliographical references (leaves 140-164). Available also in a digital version from Dissertation Abstracts.

Thesis (M. S.)--Chemical Engineering, Georgia Institute of Technology, 2008. / Committee Chair: Dr. Rachel Chen; Committee Member: Dr. Athanassios Sambanis; Committee Member: Dr. Sankar Nair. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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This research was conducted in partnership with a Nova Scotain Mi’kmaq (First Nation) community that was interested in learning more about how exposure to violence (EV) might be related to youth alcohol use. There are many consequences of childhood exposure to violence (EV), but two of the more notable consequences of EV are posttraumatic stress (PTS) symptoms and excessive or problematic alcohol misuse. Given the strong relationship in the literature between each of the PTS symptom clusters and alcohol problems, it was hypothesized that these symptom clusters would mediate the relationship between EV and alcohol misuse. Study 1 demonstrated that PTS hyperarousal symptoms, but none of the other PTS symptoms, fully mediated the relationship between EV and alcohol misuse, even after controlling for depressive symptoms, age and gender. The literature on EV also demonstrates that despite its numerous potential negative consequences, some youth continue to thrive. This thriving in the face of hardship is called resilience. Study 2 employed a direct measure of resilience (Child and Youth Resilience Measure; Ungar et al, 2008) to examine which if any aspects of resilience can successfully buffer youth from experiencing negative mental health consequences after EV. Study 2 demonstrated that all three aspects of resilience (i.e., individual, family, and community) moderated the relationship between EV and PTS reexperiencing symptoms. More specifically, at higher levels of resilience, the positive relationship between EV and PTS reexperiencing symptoms was dampened. Study 3 documented the collaborative-research process from beginning (i.e., research question formation) to end (i.e., implementation of action-based recommendations). It highlighted how the research questions outlined in Studies 1 and 2 were relevant to both the specific community in question, as well as some Aboriginal communities more broadly. It also highlighted how the first author participated in a research process that is described by the Canadian Institutes of Health Research (CIHR) as Integrated Knowledge Translation (KT). And finally, it identified via qualitative and quantitative methods how the research process as a whole has helped equip the community with more tools to tackle the problems that its members have identified as important for study and change.

A serious consequence of maternal consumption of alcohol during pregnancy is the fetal alcohol syndrome (FAS): characterized by growth deficiency (both pre- and post-natal), craniofacial dysmorphology and central nervous system (CNS) dysfunction. However, in the absence of the characteristic facial features, and without confirmed history of alcohol exposure, clinical diagnosis remains a significant challenge. Recently, the term fetal alcohol spectrum disorders (FASD) has been adopted to encompass all diagnoses relating to a history of prenatal alcohol exposure. The purpose of this study was to test the following three general hypotheses: Children with FASD 1) demonstrate specific deficits in oculomotor control that can be measured using saccadic eye movement tasks, 2) display specific deficiencies in multiple domains of executive function that can be determined using standardized neuropsychological tasks, and 3) reveal deficits in oculomotor control that correlate with deficiencies in executive function as measured using standardized neuropsychological tasks. A preliminary study revealed significant deficits in saccadic eye movement tasks and provided the foundation for a large, multi-centered study assessing oculomotor control and neuropsychological function in children with FASD. A mobile laboratory was created, which facilitated recruitment of 92 control subjects and 89 subjects with FASD. We found significant evidence for oculomotor deficits across multiple outcome measures following the saccadic eye movement experiments, especially for oculomotor tasks that probe aspects of executive function. Additionally, children with FASD exhibited performance deficits in neuropsychological tasks that assess planning, attention, spatial working memory and strategy; cognitive skills also included within the domain of executive function. Finally, significant correlations between these two objective measures were found for children with FASD, which were not evident in the control sample. These findings are consistent with significant frontal lobe dysfunction. This is an exciting area of research that may hold promise in developing effective screening tools that can assist in the diagnosis of individuals with a history of prenatal alcohol exposure. / Thesis (Ph.D, Neuroscience Studies) -- Queen's University, 2008-08-28 15:41:20.595