INTRODUCTION: Smoking, alcohol and other drugs use among high school learners has become a major public health problem across the globe. Here in South Africa, it is estimated that a large proportion of learners indulge in smoking and the use of alcohol and illicit drugs. Data from treatment sites across the country indicate that the number of patients who are below 20 years seeking treatment is escalating. These indulgences have been blamed for escalating school violence, rapes, robbery and accidents, all of which contribute to increased morbidity, disability and premature deaths. It is expected that the result of this study may provide additional understanding about learners’ drug and alcohol use. Such additional understanding can be of benefit to those responsible for the planning and implementation of cessation programmes. AIM AND OBJECTIVES: To determine the extent of drug and alcohol use, the relationship between substance use and academic performance, and the factors that may influence cessation of alcohol and drug use among high school learners in Mogalakwena municipality. METHOD: The protocol involved purposeful selection of one school from each of the nine education circuits within the Mogalakwena Municipality, Limpopo Province. The questionnaire was anonymous, requiring no data that can identify any learners. The sample consisted of five hundred and fifty five students aged 15 to 23(53% females and 47% males). The data was coded and analysed with epi-info version 6(Dutch) and this involved descriptive statistics and cross tabulations with specific reference to chi square test and students t-test yielding p-values. RESULTS: The result of this study indicate that among high school learners in the Mogalakwena municipality 28% have smoked cigarette, 65% have drunk alcohol and 16% have used illicit drugs.In addition there was statistically significant difference between urban and rural learners in terms of smoking and alcohol consumption, with higher rates among urban students, but there was no difference in the use of drugs between the two groups. Also, there was statistically significant difference in drug usage and smoking with regard to age but no difference in alcohol consumption. Younger students tended to smoke more and also were more involved in the use of drugs. More males than females were involved in smoking, alcohol consumption and drugs use. The most reported factors that could influence cessation of alcohol and drugs use were bad effect 49%, cost 23% and parents’ influence 15%. Among the parameters examined as proxies for impact of alcohol and other drugs use on academic performance, indications point to negative impact. CONCLUSION: Alcohol and other drugs use is prevalent among high school learners in the Mogalakwena municipality and is reported to have a negative impact on academic performance. “Bad effects”, high costs and significant relationships are reported as the most important factors that could influence alcohol and other drugs use cessation and these may be important considerations in planning risk reduction.

The teratogenic effects of prenatal alcohol exposure can significantly influence the development of a child, which may result in a range of structural, cognitive and behavioural abnormalities. The severity of these effects can vary and fall under the fetal alcohol spectrum disorder (FASD). South Africa hosts the highest prevalence rate (12%) of this disorder in the world. All conditions included in the FASD spectrum are completely preventable through maternal abstinence of alcohol during pregnancy. At present, very limited information is available regarding how much pregnant women in South Africa know about adverse effects caused by prenatal alcohol exposure. This study aimed to determine pregnant women’s awareness of alcohol’s potential teratogenic effects on pregnancy and their knowledge of the features and characteristics associated with fetal alcohol syndrome (FAS), the most severe of the FASD conditions. Additionally, the study compared the awareness and knowledge of pregnant women attending private antenatal centres, to those attending an antenatal clinic at Charlotte Maxeke Johannesburg Academic Hospital, a state hospital in the Johannesburg area. Participants (n=211) completed a self-administered questionnaire at their private antenatal class or state clinic. A total of 211 questionnaires were analysed; 107 questionnaires from the state antenatal clinic and 104 from the private antenatal centres. The awareness levels regarding alcohol use in pregnancy were found to be very similar amongst the private (52%) and state (55%) participants. However, results indicated that significantly more private participants (19%), compared to state participants (3%) could be classified as having knowledge of the condition FAS. Overall, this study found that pregnant women from various backgrounds have limited knowledge of the harms caused by alcohol use during pregnancy. Misconceptions about the acceptable levels of maternal alcohol consumption and the effects thereof were also evident. The results of this research highlights that prevention strategies and awareness campaigns regarding alcohol use during pregnancy should incorporate information on the severity and permanent nature of FAS, as well as highlighting the fact that all types of alcoholic beverages can result in this condition. Also, these campaigns should focus on informing women that no level of alcohol is acceptable during pregnancy, as any amount may have potentially teratogenic effects on the developing fetus.

Introduction: Alcohol is an indirect contributor to HIV transmission in sub-Saharan Africa. Alcohol users in general, and heavy, episodic drinkers in particular, are more likely to engage in risky sexual behaviour. Interventions promoting the reduction of alcohol use in conjunction with sex are likely to enhance the HIV prevention response. However, little is known about the relationship between different dimensions of alcohol use and risky sexual behaviour in the general adult population in South Africa. The overall aim of this study was to examine the relationship between alcohol dependence, binge drinking and frequency of drinking in the past month and risky sexual behaviour among males and females aged 16-55 years in South Africa in 2012. Methods: This was a secondary analysis of data from a nationally representative cross-sectional study of males and females aged 16-55 years in 2012. Bivariate and multivariate analysis was conducted to investigate the relationship between alcohol use and risky sexual behaviour. Three nuanced measures of alcohol use were used – alcohol dependence, binge drinking, and frequency of drinking in the past month. The outcomes examined included multiple sexual partners (MSP) in the past 12 months, MSP in the past month, transactional sex, age-disparate sex and condom use at last sex. Results: Some 10,034 respondents (n=4,065 males and n=5,969 females) were interviewed. This study found that for males, there was no significant relationship between alcohol dependence and risky sexual behaviour. For females, those who were alcohol dependent were more likely to have received money/gifts in exchange for sex. Binge drinking and frequency of drinking in the past month were associated with risky sexual behaviour for both males and females. For males, binge drinking was associated with: MSP in the past 12 months (AOR: 1.93, 95% CI 1.37 - 2.72), providing gifts/money in exchange for sex (AOR: 1.53, 95% CI 1.01 - 2.33), and having a sexual partner five or more years younger than themselves (AOR 1.44, 95% CI 1.09 - 1.89). An interaction between binge drinking and self-efficacy for resisting MSP was positively associated with MSP in the past month. Frequency of drinking in the previous month was associated with all five outcome variables and a dose response relationship was present. An interaction between frequency of drinking and self-efficacy for resisting MSP was positively associated with MSP in the past month. For females, binge drinking was associated with: MSP in the past 12 months (AOR 1.93, 95% CI 1.37-2.72), MSP in the past month (AOR 1.79, 95% CI: 1.03 - 3.10), and receiving money/gifts in exchange for sex (AOR 3.10, 95% CI 1.45 - 6.62). An interaction between binge drinking and self-efficacy for resisting MSP was positively associated with MSP in the 12 past months. Frequency of drinking was associated with MSP in the past month. A dose response relationship was evident with females who drank more frequently in the past month being more likely to have had MSP in the past 12 months. This study found high levels of non-drinking (62.80%) but high levels of hazardous drinking among those who drank. Males were more likely to drink and to display hazardous drinking patterns. In general males were more likely to engage in risky sexual behaviour, although males were more likely to have used a condom at last sex. Conclusions: Overall this study has described the patterns and prevalence of alcohol use and risky sexual behaviour in the general population in South Africa. It has demonstrated gender-specific relationships between various types of alcohol use and risky sexual behaviour and has new insights into the complex relationship between these two phenomena. Results suggest that the drinking environment facilitates high-risk sexual encounters. Findings from this study can be used to design and implement future interventions to address this important risk factor for HIV.

by Lee Suk Fan. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1999. / Includes bibliographical references (leaves 140-157). / Abstracts in English and Chinese. / Acknowledgements --- p.ii / Abstract --- p.iii / 槪論 --- p.v / List of Abbreviations --- p.vii / Chapter Chapter 1 --- Introduction --- p.1 / Chapter Chapter 2 --- Sex Difference in Alcohol Consumption on Hamster --- p.31 / Chapter Chapter 3 --- Effect of Chronic Alcohol Consumption --- p.65 / Chapter Chapter 4 --- Effect of Green Tea Polyphenols on Alcohol Metabolizing Enzymes in Hamster --- p.108 / Chapter Chapter 5 --- Conclusion --- p.135 / References --- p.140

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