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Pirimidinolių alkilintų darinių sintezė / Synthesis of alkylated pyrimidinolsČepulytė, Simona 13 June 2005 (has links)
In this work the alkylation of 2-ethylsulfanyl -5-methoxy-4(3H)-pyrimidinone with 4-substituted ω-bromoacetophenones, ethyl 2-bromoalkanoates and 1-bromomethyl-o-carborane was investigated. It was found that reaction of title compounds in the presence of potassium carbonate in boiling acetonitrile yielded O-alkylated derivatives with small amount of N3- and N1-alkylation products. The proportion of O- and N-alkylated products varied depending on the nature of substituent in the 4th position of benzene ring. Alkylation of title compound with ethyl bromoethanoate led to mixture of O-, N3- and N1 alkylated derivatives, while the reaction with ethyl 2-bromopropanoate yielded only O-alkylated isomer. 2-Substituted 4-pyrimidinols with nido-carborane at the side chain were synthesized. The structure of synthesized compounds was confirmed by the data of IR, UV and 1H NMR spectra.
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Furo[2,3-d]pirimidinų sintezė ir savybės / Sinthesys and chemical properties of furo[2,3-d]pirimidinesVaitiulionytė, Diana 13 June 2006 (has links)
We report herein on the results of N- and O-alkylation of 5-cyano-2-methylsulfanyl-4(3H)- pyrimidinone with 4-substituted ω-bromoacetophenones. Synthesized N-(phenacyl)-4- pyrimidinones and 4-(phenacyloxy)pyrimidines with suitable substituents in pyrimidine ring are versatile synthons for the preparation of fused pyrimidine heterocycles. Chemical properties of new furo[2,3-d]pyrimidines were investigated. The structure of synthesized compounds was confirmed by data of 1H NMR, IR and UV spectra.
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