NDLTD Global ETD Search
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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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1

Physical Dependence in Patient With Chronic Low Back Pain Treated With Topiramate: A Case Report

Bratton, Roscoe H., Ward, Sameh A. 15 November 2019 (has links)
In the last decade, prescription of anticonvulsants for treatment of low back pain (LBP) increased 4-fold. Among them, topiramate has frequent side effects and a mechanism of action that is not fully understood. The authors describe a 65-year-old woman with dependence on topiramate prescribed for chronic LBP and discuss how she was successfully weaned off topiramate using duloxetine. A significant agonistic effect by topiramate on α-2 adrenergic receptors in the brain likely accounts for the symptoms of withdrawal that were seen. We attribute the resolution of her topiramate withdrawal symptoms to reduced norepinephrine (NE) release, a known effect of duloxetine administration.
aged
adverse effects)
therapeutic use)
female
humans
low back pain (drug therapy)
receptors
adrenergic
alpha-2 (metabolism)
metabolism)
topiramate (administration & dosage
adverse effects)
treatment outcome
QCOM

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