This study was designed to evaluate the efficacy and safety of intranasal sufentanil/midazolam [S/M] and ketamine/madazolam [K/M] for sedation and analgesia in preschool children that require dental surgery [extractions].<br /> <br /> Fifty children [ASA 1] aged 5 &ndash / 7 years, requiring six or more dental extractions under general anaesthesia, were allocated to two groups of 25 children to receive either ketamine 5 mg/kg or sufentanil 20&mu / g intranasally, 20 minutes before induction of surgery in this randomised double-blind study. All the children in both groups in addition concurrently received nasal midazolam 0,3 mg/kg. For induction of anaesthesia, sevoflurane in nitrous oxide and oxygen, was used.<br /> <br /> S/M was accepted significantly better as a nasal pre-medication [p&lt / 0.05]. Both groups were equally sedated and a smooth mask induction of anaesthesia was experienced in the majority of children. Recovery of children in both groups were similar / 82% of the S/M group were fully recovered 120 minutes post-operatively versus 80% in the K/M group [p&gt / 0,05]. Effective postoperative analgesia for multiple extractions was provided. For pain evaluation, children were divided into two groups, a non-responder group where all pain values over time were more than 40 and a responder group where pain values were equal to, or less than 40. Seventy two percent of children in the S/M group were responders as to fifty two percent in the K/M group [p&gt / 0,05]. No adverse respiratory, cardiovascular or other effects were recorded. This study showed that intranasal administration of sufentanil /midazolam or ketamine/midazolam, provides safe and effective sedation and analgesia in children aged 5&ndash / 7 years undergoing multiple dental extractions.

<p>This thesis covered the fast track assessment of the referred dental patient for conscious sedation in a day clinic. The assessment took in consideration patient information, medical history, anatomical observations, treatment required, phobic aspects and patient expectations.</p>

Thesis (M. P. H.)--University of Hong Kong, 2005. / Also available in print.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2001. / Härtill 5 uppsatser.

Thesis (M.S.)--University of Michigan, 1971. / Typescript (photocopy). Includes bibliographical references (leaves 60-64). Also issued in print.

Thesis (M.S.)--University of Iowa, 2008. / Thesis supervisor: Deborah V. Dawson. Includes bibliographical references (leaves 76-83).

Thesis (M.S.)--University of Michigan, 1994. / Includes bibliographical references.

Thesis (M.S.)--University of Michigan, 1997. / Includes bibliographical references.

Thesis (M.S.)--University of Michigan, 1971. / Typescript (photocopy). eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 60-64).

Thesis (M.S.)--University of Michigan, 1994. / Includes bibliographical references.