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Self-injurious behaviors (SIBs) are relatively common in children with autism spectrum disorders (ASD), and many teachers have difficulties dealing with these challenging behaviors. Besides the possibility of causing serious injuries to children with ASD, the frequent occurrences of SIBs can limit their access to academic instruction and peer interactions. The abundance of possible strategies is confusing for teachers to figure out which strategies to use and how to implement them. The purpose of this project was to develop a guiding manual for educators working with children with ASD. The manual presents proactive, evidence-based strategies to help prevent or decrease students’ SIBs in the classroom.