The cooperation between the United States and China in central Asia is not only a kind of bilateral cooperation; they concern their mutual interests and also refer to the interests of central Asia. No matter China could accept the international reality or not, China must face the challenges after the United States enters central Asia. A safe central Asia will help China, Europe and west Asia to establish a stable connection; it will also cause better economic development and promote the international status and influence of China. The long-term interests of China in central Asia will depend on the cooperation between other superpowers, so China must strengthen the cooperation between America and Russia in order to stable the safety of central Asia. Besides, central Asia plays an important role on the economic and military safety of China. Therefore, in order to maintain the stable development and power balance in central Asia, the United States and China must keep the competitive and cooperative relationship in the future.