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Multifunctional electrospun nanofibers incorporated with an anti-infection drug and immobilized with proteinsZhou, Shufei 16 August 2010 (has links)
Electrospinning is a novel technique to fabricate non-woven fibers with sizes ranging from nano to micrometers. Polymers have been electrospun into nanofibers that can be developed into desirable materials with excellent biocompatibility and biodegradability for biomedical applications in wound healing and tissue regeneration. These nanofiber materials can be further functionalized to be loaded with bioactive molecules, including antibacterial agents, functional proteins that promote tissue reconstruction while protect host tissues from contamination. This study focuses on the development of multifunctional nanofibers that are incorporated with antibacterial drug(s) and immobilized with bioactive proteins. These nanofibers are potentially useful for wound care and tissue engineering scaffolding to provide both infection control and promotion of wound healing or tissue regenerations.
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Multifunctional electrospun nanofibers incorporated with an anti-infection drug and immobilized with proteinsZhou, Shufei 16 August 2010 (has links)
Electrospinning is a novel technique to fabricate non-woven fibers with sizes ranging from nano to micrometers. Polymers have been electrospun into nanofibers that can be developed into desirable materials with excellent biocompatibility and biodegradability for biomedical applications in wound healing and tissue regeneration. These nanofiber materials can be further functionalized to be loaded with bioactive molecules, including antibacterial agents, functional proteins that promote tissue reconstruction while protect host tissues from contamination. This study focuses on the development of multifunctional nanofibers that are incorporated with antibacterial drug(s) and immobilized with bioactive proteins. These nanofibers are potentially useful for wound care and tissue engineering scaffolding to provide both infection control and promotion of wound healing or tissue regenerations.
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ATIVIDADE Antimicrobiana e Antibiofilme da Epigalocatequina Galato em Staphylococcus AureusKNIDEL, C. 06 March 2018 (has links)
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Previous issue date: 2018-03-06 / As infecções bacterianas estão entre os principais problemas para a saúde pública e o surgimento de bactérias resistentes aos antimicrobianos se torna cada vez mais comum. Staphylococcus aureus é um patógeno oportunista, que pode causar uma variedade de infecções, tanto hospitalares como comunitárias. A epigalocatequina galato (EGCG), flavonoide presente nas folhas da planta Camelia sinensis, vem sendo estudada por apresentar diferentes atividades biológicas, incluindo potencial atividade antimicrobiana. O objetivo do presente trabalho foi avaliar o potencial antimicrobiano, in vitro e in vivo, e antibiofilme da EGCG em isolados clínicos de S. aureus com diferente background genético. Foram utilizadas nove amostras isoladas de diferentes infecções, com distinta susceptibilidade aos antimicrobianos. A atividade antimicrobiana foi realizada por teste de microdiluição em caldo para a determinação da concentração mínima inibitória (CMI) e pelo ensaio de curva tempo-morte. Os resultados das CMIs variaram de 7,81 a 62,5 μg/mL e uma atividade bactericida foi observada com o tratamento de 4x a CMI. A atividade antibiofilme foi avaliada após a incubação dos isolados na presença e ausência da EGCG. Concentrações sub-inibitórias foram capazes de inibir de forma significativa a produção de biofilme de S. aureus. Com o tratamento, a maior redução na produção de biofilme foi de 100% e as menores entre 50 a 60%. Ensaios de citotoxicidade mostraram que concentrações ≤ 62,5 μg/mL da EGCG não foram citotóxicas para macrófagos murinos. Em relação ao teste in vivo utilizando larvas de G. mellonella, a EGCG reduziu a mortalidade das larvas infectadas por este patógeno de forma significativa (P=0,0005) frente a apenas um isolado. De forma geral, a EGCG mostrou eficácia em inibir o crescimento de diferentes isolados clínicos de S. aureus e apresentou relevante propriedade antibiofilme. O tratamento in vivo com larvas de G. mellonella mostrou efeito variável. Portanto, a EGCG é uma substância promissora para o tratamento de infecções causadas por S. aureus.
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Anticancer, antifungal and antibacterial potential of bis(β-ketoiminato)ruthenium(II) carbonyl complexesMadzivire, C.R., Carames-Mendez, P., Pask, C.M., Phillips, Roger M., Lord, Rianne M., McGowan, P.C. 08 September 2019 (has links)
No / Herein we report a library of new ruthenium(II) complexes which incorporate a range of functionalised β -ketoiminate ligands. The complexes undergo an unusual reduction from Ru(III) to Ru(II), and consequently incorporate carbonyl ligands from the 2-ethoxyethanol solvent, forming ruthenium dicarbonyl complexes. In order to address the potential applications of these complexes, we have screened the library against a range of tumour cell lines, however, all compounds exhibit low cellular activity and this is tentatively assigned to the decomposition of the compounds in aqueous media. Studies to establish the antifungal and antibacterial potential of these complexes was addressed and show increased growth inhibitions for C. neoformans and S. aureus species. / The authors would like to thank the universities of Leeds, Huddersfield and Bradford for internal financial support.
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Sustained Drug Release And Antibacterial Activity Of Ampicillin incorporated Poly (methyl methacrylate)-Nylon6 Core/Shell NanofibersSohrabi, Amirreza Unknown Date
No description available.
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