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noneWang, Yun-Herng 29 June 2001 (has links)
The antibiotic-resistant bacteria seriously threaten public heath. Scientists of both public and private sectors are devoted to develop new drugs to overcome this problem. Marine species are highly diversity and have been shown to be a potential sources to find efficient compounds. The medicine application of the natural products from ocean increases in last decade. The purpose of the project was to isolate antibiotic-producers from sea-bottom mud. Three filament microorganisms from marine environment, Acremonium altematum T1-1, Aspergillus ochraceus N7 and Nocardiopsis dassonvillei F5, can produce bioactivity compounds. All compounds purified using silica chromatographic separation from culture extraction and determination of their structure by NMR spectrum and X-ray diffraction pattern for crystals. A. altematum T1-1 produced 5,6-dihydropenicillic acid (DHPA), A. ochraceus N7 produced penicillic acid (PA), and N. dassonvillei F5 produced iodinin. The structures of DHPA and PA were identified as derivatives of five-member lactone, and iodinin is a derivative compound of phenazine. The optimal growth of DHPA -producer A. altematum T1-1 was in 6% salinity at 30¢J and best DHPA production was in 0% salinity at 25¢J. The optimal growth of PA-producer A. ochraceus N7 was in 6% salinity at 25¢J, and best PA production conditions was below 3% salinity at 25 ¢J. The optimal growth of iodinin-producer N. dassonvillei F5 was in 6% salinity at 30¢J and best iodinin production condition was 1-3% salinity at 25¢J. Only PA has highly inhibited of B. cereus at the MIC of 75 mg/ml. The PA had cytotoxicity against cancer cell lines of P-388, HT-29 and A549 while iodinin inhibited P-388 and A549. The ED50 on the swimming ability of rotifer was 1.03 and 2.5 mg/ml for PA and DHPA, respectively. It revealed that the growth of these two mold can occur in regular marine environment and produce toxin to kill rotifer. The growth of N. dassonvilleiand F5 and iodinin caused the death and virus-invasion of shrimp.
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A Wait-and-See Prescription for the Treatment of Acute Otitis Media: A Randomized, Controlled TrialTay, Khoon-Yen Elisa 15 November 2006 (has links)
Acute otitis media (AOM) is the most common diagnosis for which antibiotics are prescribed for children in the United States. Previous trials evaluating an optional antibiotic prescription are limited and have significant limitations. None have evaluated an optional prescription in the urgent care setting. We conducted a randomized, controlled trial in an urban emergency department in which children aged 6 months to 12 years diagnosed with AOM were randomly assigned a "wait-and-see prescription" (WASP) or a "standard treatment prescription" (STP). Structured phone interviews were conducted 4-6, 11-14, and 30-40 days after enrollment to determine the proportion of each group that filled the antibiotic prescription and outcomes related to the clinical course. Substantially more parents in the WASP group (N=138) did not fill the antibiotic prescription compared to the STP group (N=145) (62% vs. 13%; P<0.001). There were no statistically significant differences between the groups in the frequency of subsequent fever, otalgia or unscheduled visits for medical care. Within the WASP group, both fever (OR = 4.0, 95% confidence interval, 1.7-9.5) and otalgia (OR = 4.5, 95% confidence interval, 1.7-11.5) were associated with filling the prescription. The WASP approach substantially reduced unnecessary use of antibiotics in children and is a reasonable alternative to routine use of antimicrobials for treatment of AOM.
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Structural analysis of 5'-Methylthioadenosine/S-Adenosylhomocysteine nucleosidase from Helicobacter pylori for the purpose of drug development /Iacopelli, Natalie Marie. January 2009 (has links)
Thesis (M.S.)--University of Toledo, 2009. / Typescript. "Submitted as partial fulfillment of the requirements for The Master of Science degree in Chemistry." "A thesis entitled"--at head of title. Bibliography: leaves 100-104.
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Modulation of acute inflammatory response caused by surgical trauma in a mastectomy modelChow, Wing-cheong, Louis. January 1999 (has links)
Thesis (M.S.)--University of Hong Kong, 1999. / Includes bibliographical references (leaves 140-168).
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Chemistry of antibiotics from Atlantic actinomycete and bacillus bacteria /Socha, Aaron Martin. January 2008 (has links)
Thesis (Ph.D.) -- University of Rhode Island, 2008. / Typescript. Includes bibliographical references (leaves 335-353).
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Examination of the effect of reduction of probiotic species Lactobacillus due to broad spectrum antibiotic treatment on oral toleranceRider, Kelly N. January 2009 (has links)
Thesis (M.S.)--Ball State University, 2009. / Title from PDF t.p. (viewed on Dec. 14, 2009). Includes bibliographical references (p. 74-76).
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Novel methodologies for the synthesis of C-aryl glycosides and progress toward the synthesis of the C-aryl glycoside natural products galtamycinone and kidamycinKaelin, David Earl. January 2002 (has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2002. / Vita. Includes bibliographical references. Available also from UMI Company.
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Isolation and characterization of reaction intermediates of the CerA metallo-beta-lactamase under cryokinetic conditions /Huang, Victor Wei-Shyue. January 2003 (has links)
Thesis (Ph. D.)--University of Chicago, Dept. of Biochemistry and Molecular Biology, August 2003. / Includes bibliographical references. Also available on the Internet.
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Study of structure-function relationships in cationic antimicrobial peptides derived from human and porcine lactoferricins /Chan, Mei-sheung, January 2010 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2010. / Includes bibliographical references (leaves 196-245). Also available online.
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Study of structure-function relationships in cationic antimicrobial peptides derived from human and porcine lactoferricinsChan, Mei-sheung, January 2010 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2010. / Includes bibliographical references (leaves 196-245). Also available in print.
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