- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 1 to 10 of 72 (0.06 seconds)| 1 |
An investigation of the induction of vincristine and multidrug resistance in Chinese hamster ovary cells following exposure to hydroxyurea or adriamycinSwingler, Lisa G. January 1991 (has links)
No description available.
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Pharmacokinetics of 5-fluorouracil in cancer patientsWattanatorn, Wiboon January 1998 (has links)
No description available.
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Design, synthesis and evaluation of a scaffold and capping units based on the pyrrolo[2,1-c][1,4]benzodiazepines for combinatorial chemistryGonzaliez, Laura Maritza Calderon January 2000 (has links)
No description available.
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Evaluation of novel compounds to modulate the cytotoxicity of anticancer agents in mammalian cellsBowman, Karen Julia January 1999 (has links)
No description available.
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Structure/activity relationships of antitumour diazridinylquinonesShahbakhti, Hassan January 1996 (has links)
No description available.
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Studies on the pharmacokinetics and metabolism of mitozantronePriston, Melanie Jane January 1991 (has links)
No description available.
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The mechanism of action of antitumour lipid agents related to platelet-activating factor (PAF)Lohmeyer, Matthias January 1994 (has links)
No description available.
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Molecular analysis of verapamil hypersensitive multidrug resistant hamster cell linesStow, Martin William January 1990 (has links)
No description available.
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Novel pharmacology of the lipophilic antifolate methylbenzoprimCroughton, Karen January 2001 (has links)
No description available.
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Multidrug resistance in Candida albicansClark, Fiona S. January 1994 (has links)
Azole-resistance in Candida albicans is becoming common and is associated with the widespread prophylactic use of azoles. Resistance to one azole is usually associated with resistance to other structurally dissimilar azoles. C.albicans is also inherently resistant to a wide range of eukaryotic inhibitors such as cycloheximide and gentamycin. Certain studies have shown that azole-resistance in some strains of C.albicans is associated with alterations in the cell membrane. This project has sought to determine whether azole-resistance in C.albicans strain 3302 was due, at least in part, to a multidrug resistance mechanism. An assay was developed using the fluorescent dye Rh123 to measure P-glycoprotein like activity. Active efflux of Rh123 has been shown to correlate with P-glycoprotein activity in a number of organisms. Results from this assay suggest that an energy-dependent efflux mechanism for Rh123 is present in azole-resistant strain 3302 but not in azole-sensitive strain 3153. The P-glycoprotein inhibitor, reserpine, inhibited Rh123 efflux. However, azoles did not appear to compete with Rh123 for efflux in the azole-resistant strain 3302, suggesting that azole-resistance in this strain is not mediated by a P-glycoprotein like mechanism. Southern analysis showed that sequences homologous to MDR genes existed in C.albicans. A PCR strategy was used to clone gene fragments containing the Walker motif which is found in MDR genes.
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