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Convenient Preparation of 2,7,8-Trimethyl-6-Hydroxychroman-2-Carboxylic Acid (γ-Trolox)Hyatt, John 01 January 2008 (has links)
The title chroman is useful in synthesis and as a water-soluble analog of γ-tocopherol, a member of the vitamin E family. This new synthesis of γ-trolox proceeds via selective aromatic demethylation of Trolox, the more easily available 2,5,7,8-tetramethyl homolog compound. This route is shorter than the previous synthesis, avoids the use of cyanide and methoxybutadiene, and requires no chromatography.
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