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Development of ultrasonic devices for microparticle and cell manipulationQiu, Yongqiang January 2014 (has links)
An emerging demand for the precise manipulation of cells and microparticles for applications in cell biology and analytical chemistry has driven recent development of ultrasonic manipulation technology. Compared to the other major technologies used for cell and particle manipulation, such as magnetic tweezing, optical tweezing and dielectrophoresis, ultrasonic manipulation has shown excellent capabilities and flexibility in a variety of applications with its advantages of versatile, inexpensive and easy integration into microfluidic systems, maintenance of cell viability, and generation of sufficient forces to handle cells with dimensions up to tens of microns and agglomerates of a large number of cells. This thesis reviews current state-of-the-art of ultrasonic manipulation technology and reports the development of various ultrasonic manipulation devices, including simple devices integrated with high frequency (> 20 MHz) ultrasonic transducers for the investigation of biological cells and complex ultrasonic transducer array systems to explore the feasibility of electronically controlled 2-D and 3-D manipulation. Piezoelectric and passive materials, fabrication techniques, characterisation methods and possible applications are discussed. The behaviour and performance of the devices have been investigated and predicted in virtual prototyping with computer simulations, and verified experimentally. Issues associated during the development are highlighted and discussed. To assist long term practical adoption, approaches to low-cost, wafer level batch-production and commercialisation potential are also addressed.
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Fabrication of ultrasound transducers and arrays integrated within needles for imaging guidance and diagnosisMcPhillips, Rachael January 2017 (has links)
As opposed to current Intraoperative Ultrasound (IOUS) systems and their relatively large probes and limited superficial high frequency imaging, the use of a biopsy needle with an integrated transducer that is capable of minimally invasive and high-resolution ultrasound imaging is proposed. Such a design would overcome the compromise between resolution and penetration depth which is associated with the use of a probe on the skins surface. It is proposed that during interventional procedures, a transducer array positioned at the tip of a biopsy needle could provide real-time image guidance to the clinician with regards to the needle position within the tissue, and aid in the safe navigation of needles towards a particular target such as a tumour in tissues such as the breast, brain or liver, at which point decisions surrounding diagnosis or treatment via in vivo tissue characterisation could be made. With this objective, challenges exist in the manufacturing these miniature scale devices and theirincorporation into needle packages. The reliable realisation of miniature ultrasound transducer arrays on fine-scale piezoelectric composites, and establishing interconnects to these devices which also fit into suitably sized biopsy needles are two such hurdles. In this thesis, the fabrication of miniature 15 MHz ultrasound transducers is presented. The first stage of development involved the production of single element transducers in needles ~2 mm inner diameter, using various piezoelectric materials as the active material. These devices were tested andcharacterised, and the expertise developed during their fabrication was used as the foundation upon which to design a wafer-scale fabrication process for the production of multiple 15 MHz transducer arrays. This process resulted in a 16 element 15 MHz array connected to a flexible printed circuit board and integrated into a breast biopsy needle. Characterisation tests demonstrated functionality of each of the 16 elements, both individually and combined as an array. To explore potential applications for these devices, the single element transducers were tested in fresh and Thiel embalmed cadaveric brain tissue. Plasticine targets were embedded in these brain models and the needle transducers were tested as navigational real-time imaging tools to detect these targets within the brain tissue. The results demonstrated feasibility of such devices to determine the location of the target as the needle devices were advanced or withdrawn from the tissue, showing promise for future devices enabling neurosurgical guidance of interventional tools in the brain. The application of breast imaging was also considered. Firstly, Thiel embalmed cadaveric breasts were assessed as viable breast models for ultrasound imaging. Following this, anatomical features, with diagnostic significance in relation to breast cancer i.e. axillary lymph nodes and milk ducts, were imaged using a range of ultrasound frequencies (6 – 40 MHz). This was carried out to determinepotential design parameters (i.e. operational frequency) of an interventional transducer in a biopsy needle probe which would best visualise these features and aid current breast imaging and diagnosis procedures.
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Analogues Between Leibniz's Harmonic Triangle and Pascal's Arithmetic TriangleJames, Lacey Taylor 01 June 2019 (has links)
This paper will discuss the analogues between Leibniz's Harmonic Triangle and Pascal's Arithmetic Triangle by utilizing mathematical proving techniques like partial sums, committees, telescoping, mathematical induction and applying George Polya's perspective. The topics presented in this paper will show that Pascal's triangle and Leibniz's triangle both have hockey stick type patterns, patterns of sums within shapes, and have the natural numbers, triangular numbers, tetrahedral numbers, and pentatope numbers hidden within. In addition, this paper will show how Pascal's Arithmetic Triangle can be used to construct Leibniz's Harmonic Triangle and show how both triangles relate to combinatorics and arithmetic through the coefficients of the binomial expansion. Furthermore, combinatorics plays an increasingly important role in mathematics, starting when students enter high school and continuing on into their college years. Students become familiar with the traditional arguments based on classical arithmetic and algebra, however, methods of combinatorics can vary greatly. In combinatorics, perhaps the most important concept revolves around the coefficients of the binomial expansion, studying and proving their properties, and conveying a greater insight into mathematics.
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UHF and Microwave Phase-Modulated Scattering ArrayAlkhafaji, Nasr Nomas Hussein 05 June 2019 (has links)
This dissertation investigates the use an array of active nonlinear elements, with particular emphasis on controlling distortion products generated by nonlinear elements in space rather than using conventional ways such as transmission lines, waveguides, and power dividers and combiners. The nonlinear elements are made of assemblies of antennas and electronic switches, called modulated scatterers (MSs). These so-called MSs elements are utilized in a wide variety of applications such as radio frequency identification (RFID) systems, microwave imaging, Internet-of-Things sensors, etc. However, no research work has been reported in the literature regarding exploiting and controlling several distortion products generated by MSs at the same time according to the best of authors' knowledge. To facilitate controlling distortion products which means suppressing or enhancing distortion products in space, we present a nonlinear array with elements that are MSs instead of conventional antennas. MSs are switched ON-OFF at different times by modulation signals having the same frequency. The time delay of the switching process between array elements represents a relative phase shift difference in the frequency domain. Thus, the presented structure is called the phase-modulated scattering array (PMSA). The PMSA has a similar layout of phased arrays, but it does not have a feeding network and is fed by an external source called the illuminating source. Because our system does not need a feeding network and phase shifters, it is potentially easier to implement with low cost. Two different signals which are the illuminating (incident) and modulation signals interact inside switches to generate a huge number of distortion products due to the nonlinearity of switches and the periodic nature of the presented system. Distortion products then leave the presented PMSA to space again (i.e., scattering distortion products). The PMSA is able to treat distortion products and achieve beamforming functions.
The operation mechanism of the PMSA is explained by developing two different mathematical models. Communication signal processing perspectives are the basis of the first mathematical model developed to show the spatial characteristics of distortion products generated by our presented PMSA. Its root is originated from a mathematical model of the widely-used polyphase multipath technique in RF communication circuits. However, the adopted technique is suitable only for communication circuits with a single output and parameters prescribed in advance. Thus, the model is further developed to circumvent all the problems mentioned above and to be able to detect the spatial characteristics of distortion products at any point in space. Static impacts of the measurement environment, real radiation patterns of actual antennas utilized in prototypes, and phase and gain errors among paths have been taken into account as well. In the model, every single scatterer is represented by a single separate path. Furthermore, the modified model is extended to include single, two, and multi tones modulation signals. Simulation results have been obtained before and after the modification for a different number of paths and modulation signals with different tones. Results show that the modified model can quantify spatial characteristics of distortion products at any point in space where specific distortion products are enhanced, and others are canceled. Because distortion products are independent in their nature (i.e., each single distortion product has different frequency and phase), they have independent radiation patterns (scattered beams). Therefore, the second mathematical model based on phased antenna array perspectives is developed. The relationship between the two models states that a distortion product which is enhanced at a certain point in space has a maximum scattered beam at that point. Also, the second mathematical model being similar to mathematical models of phased arrays considers effects of all distortion products resulting from single, two, and multi tones modulation signals, and it states that each single distortion component has its particular scattered beam.
Next, sub-models for some properties and applications of the presented PMSA such as a diffraction grating-like behavior, nonreciprocity, beamforming, a tool for distortion product analysis of phased arrays and multi-input multi-output (MIMO systems), a reconfigurable-spatial harmonic generator, and a direction finding technique are derived depending on the two main mathematical models. All parts are simulated and results validate all proposed functionalities.
Single antennas, antenna arrays, electronic switches (modulators), and a 4-to-8 phase transformer kit using only resistors have been designed, simulated, fabricated, assembled, and tested.
Eventually, different structures of the presented PMSAs working at 432MHz and 2.3GHz are tested inside the anechoic chamber. Both frequencies are downconverted to the band 2-22kHz. Modulation signals used in the experimental setups are single and two tones. Data are measured using the commercial software SigView running on a laptop and a spectrum analyzer. Both spatial characteristics and scattered beams of distortion products are measured. Comparisons have been made between measured received responses of scattered signals and theoretical results. They are in good agreement although limitations and challenges are encountered with each round of measurement. Measured results confirm practically that as a number of scatterers increases, more distortion products are controlled at the same time. The distortion product rejection ratio DPRR is more than 15dB for all measured distortion products supposed to be canceled. Directions of scattered beams are found at expected locations with errors less than 3%. Furthermore, directions of illuminating signals or distances separating between PMSA elements are varied to change directions of scattered beams when prescribed values of parameters governing the overall performance are being broken. In other words, the beamforming functionality has been validated practically. Different elements of 8*1-PMSA are turned-off at measurements in order to find fault tolerances of the presented system. Measured results show that when two elements are failed simultaneously, responses can be accepted to some extent.
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Robust beamforming for collaborative MIMO-OFDM wireless systemsKwun, Byong-Ok. January 2007 (has links)
No description available.
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Applications of microwave holography to the assessment of antennas and antenna arraysZhang, Tieren, University of Western Sydney, College of Science, Technology and Environment, School of Engineering and Industrial Design January 2001 (has links)
Gabor's original holography, which is the basic theory of modern microwave holographic techniques, is introduced. By computer simulations, it is demonstrated that the conventional holographic approach can be used as a tool to reconstruct aperture field distributions of an antenna with some constraints. Computer simulations of the theory and technique of the improved microwave holographic approach originally introduced by Rahmat-Samii et al. are carried out. The results show that it can be used for surface distortion diagnosis of large reflector antennas. The physical optics integral formulation is derived by general solutions of the vector wave equations. The necessary theory , which is needed to reconstruct the aperture field from near-field measurements both in a rectangular coordinate system and in a cylindrical coordinate system is developed. It is based on the plane wave spectrum and the vector wave modal expansion of an electromagnetic field. By using a simple dipole and other well-defined antennas, computer simulations have been performed. The results show that the technique is rigorous and applicable. It is also demonstrated that the sampling intervals and the number of sampling points should be chosen carefully in order to obtain a satisfactory resolution of the reconstructed aperture field. Furthermore, the simulations carried out in this work reveal that the real aperture field distribution of a dipole antenna has a maximum point at each end of the antenna. This characteristic can only be obtained at a very close distance to the antenna. This study also reveals the significant contributions of the evanescent waves to the aperture reconstruction. A simple but effective method for examining the evanescent waves from the measured near-field is also presented. By using dipoles and other well known antennas and antenna arrays, the experiments were carried out. The experimental results provide reasonable good agreements with the simulations. The technique proposed is effective and accurate. / Doctor of Philosophy (PhD)
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Arrival directions of medium energy cosmic rays in the southern hemisphere / David John BirdBird, David John, 1965- January 1991 (has links)
Bibliography : leaves i-xx / xi, 168, [99], xx leaves : ill ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.)--University of Adelaide, Dept. of Physics and Mathematical Physics, 1991
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Fabrication of Highly Ordered Nanoparticle Arrays Using Thin Porous Alumina MasksLei, Y., Teo, L.W., Yeong, K.S., See, Y.H., Chim, Wai Kin, Choi, Wee Kiong, Thong, J.T.L. 01 1900 (has links)
Highly ordered nanoparticle arrays have been successfully fabricated by our group recently using ultra-thin porous alumina membranes as masks in the evaporation process. The sizes of the nanoparticles can be adjusted from 5-10 nm to 200 nm while the spacing between adjacent particles can also be adjusted from several nanometers to about twice the size of a nanoparticle. The configuration of the nanoparticles can be adjusted by changing the height of the alumina masks and the evaporation direction. Due to the high pore regularity and good controllability of the particle size and spacing, this method is useful for the ordered growth of nanocrystals. Different kinds of nanoparticle arrays have been prepared on silicon wafer including semiconductors (e.g., germanium) and metals (e.g., nickel). The germanium nanoparticle arrays have potential applications in memory devices while the nickel catalyst nanoparticle arrays can be used for the growth of ordered carbon nanotubes. / Singapore-MIT Alliance (SMA)
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Sparsely Faceted Arrays: A Mechanism Supporting Parallel Allocation, Communication, and Garbage CollectionBrown, Jeremy Hanford 01 June 2002 (has links)
Conventional parallel computer architectures do not provide support for non-uniformly distributed objects. In this thesis, I introduce sparsely faceted arrays (SFAs), a new low-level mechanism for naming regions of memory, or facets, on different processors in a distributed, shared memory parallel processing system. Sparsely faceted arrays address the disconnect between the global distributed arrays provided by conventional architectures (e.g. the Cray T3 series), and the requirements of high-level parallel programming methods that wish to use objects that are distributed over only a subset of processing elements. A sparsely faceted array names a virtual globally-distributed array, but actual facets are lazily allocated. By providing simple semantics and making efficient use of memory, SFAs enable efficient implementation of a variety of non-uniformly distributed data structures and related algorithms. I present example applications which use SFAs, and describe and evaluate simple hardware mechanisms for implementing SFAs. Keeping track of which nodes have allocated facets for a particular SFA is an important task that suggests the need for automatic memory management, including garbage collection. To address this need, I first argue that conventional tracing techniques such as mark/sweep and copying GC are inherently unscalable in parallel systems. I then present a parallel memory-management strategy, based on reference-counting, that is capable of garbage collecting sparsely faceted arrays. I also discuss opportunities for hardware support of this garbage collection strategy. I have implemented a high-level hardware/OS simulator featuring hardware support for sparsely faceted arrays and automatic garbage collection. I describe the simulator and outline a few of the numerous details associated with a "real" implementation of SFAs and SFA-aware garbage collection. Simulation results are used throughout this thesis in the evaluation of hardware support mechanisms.
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High Density Single Crystalline GaN Nanodot Arrays Fabricated Using Template-Assisted Selective GrowthWang, Yadong, Zang, Keyan, Chua, Soo-Jin, Fonstad, Clifton G. Jr. 01 1900 (has links)
High density, uniform GaN nanodot arrays with controllable size have been synthesized by using template-assisted selective growth. The GaN nanodots with average diameter 40nm, 80nm and 120nm were selectively grown by metalorganic chemical vapor deposition (MOCVD) on a nano-patterned SiO2/GaN template. The nanoporous SiO2 on GaN surface was created by inductively coupled plasma etching (ICP) using anodic aluminum oxide (AAO) template as a mask. This selective regrowth results in highly crystalline GaN nanodots confirmed by high resolution transmission electron microscopy. The narrow size distribution and uniform spatial position of the nanoscale dots offer potential advantages over self-assembled dots grown by the Stranski–Krastanow mode. / Singapore-MIT Alliance (SMA)
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