No description available.

No description available.

This study via the literatures and expert¡¦s interviews to explore the currently problems of new venture incubator to domestic Web2.0 industry, then try to offer the helpful suggestion. First, the way of analyzing literatures and correlating dates, can get the general problems during enterprise. This study focus on the pre start up stage and start up stage then choose the controllable factors and made the chosen factor as the content of expert¡¦s interview. This study chosen four factors ¡§the path of enterprise¡¨,¡¨ the recourses of enterprise¡¨, ¡§specific assistance of enterprise¡¨, ¡§the enterprise team¡¨ as the basic analyzing frame, , and get the results through expert¡¦s interview. By this study find out enterprise behavior can receive a appreciable profit. Recently, the industry orientations have gradually changed from labor-intensive industry to knowledge-intensive industry, and the information technology and infrastructure are nearly complete. Therefore this study chooses Web2.0 industry as research target. To observe the current circumstance of domestic enterprise assistance system can acquire preliminary phenomenon that current assistance system is lack of resource of pre start up stage and start up stage. It always makes enterprise behavior vanish even if the enterprisers have a fantasy idea. Comparatively a foreign country as U.S.A has lots of assistance institutions in connection with Web2.0 enterprise and has assisted the enterpriser establishes the company. Therefore, this study hopes to design an ideal model for domestic Web2.0 industry.

This research paper highlights the significance of mock circulatory loops in aiding the development and testing of left ventricle assist devices (LVADs). Heart disease is the leading cause of death in America, and LVAD offers an effective solution to patients with severe coronary artery disease who are not eligible for heart transplants. However, before testing LVADs in-vivo, extensive performance and reliability testing is required as per Food and Drug Administration guidelines. Mock circulatory loops are useful for simulating the cardiac cycle and capturing pressure and flow meter readings. The research focused on developing and testing a mock circulatory loop that accurately captures pressure and flow meter readings. The team experimented with various silicone elastomers and a urethane-based material, ClearFlex 30, to create a transparent phantom. The report highlights the importance of surface roughness for optical clarity, with an average surface roughness of 0.186 μ being ideal for optimal clarity achieved with 800-grit sandpaper. The impact of pressure differences between the aortic and mitral inlet/outlets was also studied, and it was found that the loop's resistance can be modified to achieve elevated pressure in the aortic outlet. The report further emphasized the importance of refractive index matching to perform particle image velocity. Matching the refractive index of the phantom with the medium is critical to avoid distortion and refraction of the light. Glycerol water was found to be an effective medium for refractive index matching. Overall, the successful testing of the mock circulatory loop provides valuable insights into the flow structure within the heart, aiding in the development of future LVADs. This research is significant in advancing the cardiology field and will potentially benefit many patients suffering from heart disease. / Master of Science / This research paper focuses on developing and testing left ventricle assist devices (LVADs) using a mock circulatory loop tool. Heart disease is a leading cause of death in America, and LVADs provide an effective solution for patients with severe coronary artery disease who are not eligible for heart transplants. However, before testing LVADs on humans, extensive performance and reliability testing is required as per Food and Drug Administration guidelines. Mock circulatory loops are a tool that helps simulate the cardiac cycle and capture pressure and flow meter readings. The researchers developed and tested a mock circulatory loop that could accurately capture pressure and flow meter readings. They used various materials to create a transparent phantom that allowed them to see inside the loop. The researchers found that the surface roughness of the phantom was important for optical clarity, and they achieved optimal clarity using 800-grit sandpaper. They also studied the impact of pressure differences between the aortic and mitral inlet/outlets. They found that the loop's resistance can be modified to achieve elevated pressure in the aortic outlet. To study the flow structure within the heart, the researchers used a technique called particle image velocity. They emphasized the importance of refractive index matching, which helps avoid distortion and refraction of light. The researchers found that glycerol water was an effective medium for refractive index matching. Overall, the successful testing of the mock circulatory loop provides valuable insights into the flow structure within the heart, aiding in the development of future LVADs. This research has significant implications for advancing the cardiology field and potentially benefitting many patients suffering from heart disease.

<div>Mission designs have been focused on using proven orbital maneuvers (i.e., propulsive maneuvers and gravity-assist) to deliver spacecraft to planetary destinations. Aeroassist maneuvers, despite their potential benefits, have not been given serious considerations due to the perceived risk and complexity. As entry technologies mature, aeroassist maneuvers need to be considered more extensively. Currently, there is no tool available that can perform rapid preliminary mission designs using aeroassist maneuvers. In this dissertation, integrated design methodologies for aerocapture and aerogravity-assist are developed, which can be readily converted to design tools that enable rapid mission concept formulations. </div><div> </div><div>The aerocapture design methodology is used to develop extensive design rules and relations for aerocapture missions to Titan, Venus, and Uranus, considering a wide range of vehicle parameters and interplanetary trajectories. These design rules and relations are intended as a convenient resource for mission designers and system engineers to evaluate the feasibility of aerocapture (e.g., effects of V-infinity on aerocapture missions) and the relevant design requirements, such as choices for vehicle characteristics and TPS materials. In addition, potentials for inclination change for Titan aerocapture are also quantified, presenting additional benefits of using aerocapture. Given the unusual orientation of Uranus, the changes in inclination and shift of line of apsides are also quantified for Uranus aerocapture. </div><div> </div><div>A novel design methodology is developed for Saturn system missions using nontraditional aerogravity-assist maneuvers at Titan. Compared with the existing literature, the novel methodology explores a comprehensive design space by integrating design considerations for interplanetary trajectories, atmospheric trajectories, arrival geometries at Titan, and vehicle designs. The methodology enables preliminary design trades and allows the mission designer to assess the feasibility of Titan aerogravity-assist and quickly develop requirements for trajectory designs and vehicle designs. The methodology also identifies potential Saturn and Titan arrival conditions. Results for an example Enceladus mission and Saturn system mission are presented, showing that a Saturn arrival V-infinity of 7 km/s renders Titan aerogravity-assist feasible for an Enceladus mission, while using the current entry technology. </div><div> </div><div>Bank modulation and drag modulation have been considered separately for aeroassist vehicles in the literature. The investigation combines bank modulation and drag modulation to improve the control authorities for aeroassist vehicles and such improvements are quantified using numerical simulations for a wide range of vehicle design configurations. The results show the potential of using a low-L/D vehicle for aerocapture at Uranus using combined bank and drag modulation. </div><div><br></div>

Current one-handed manual wheelchairs are difficult to propel because one arm can only provide half the power that is ascertained in a two-handed manual wheelchair. A power-assisted hemiplegic (one-sided paralysis) wheelchair was developed that can effectively be propelled with one arm while remaining maneuverable, lightweight, and foldable. An existing manual wheelchair was minimally modified and fitted with powerassisted components that could alternatively be attached to a wide range of manual wheelchairs. The design implements a motor and gear train to power the wheel on the user’s affected side, encoders on both rear wheels to track wheel position, and a heel interface on the footrest to control steering. A controls program was developed that analyzes wheel position and steering to respond to the motion of the hand-driven wheel. Extensive testing was performed to ensure design integrity. Testing results showed that the prototype successfully met and exceeded predetermined design specifications based on industry standard testing procedures. The design has the potential to deliver increased freedom to a considerable consumer base.

Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003. / Includes bibliographical references (p. 71-72). / by Rebecca Anne Hitchcock. / M.Eng.

Congestive heart failure (CHF) is a debilitating condition that afflicts 4.8 million Americans with an increasing incidence. Each year, there are an estimated 400,000 new cases. The incidence is on the rise as the age of the population is increasing and because most people are surviving their first heart attack. Pharmacological therapies are improving, yet many patients still reach end-stage heart failure and there are too few donor hearts available. This thesis is presented as a first small step in a long process in the design and development of a novel cardiac assist device that would ultimately heal a diseased heart by the process of ventricular recovery. The device acts to restore the kinematics of a diseased heart by modulating the extra ventricular displacements. The first surgery / trial were conducted on a bovine at the Veterinary School at Texas A&M University. Main objectives of the surgery were to test the method of attachment of the device and power requirements of the device. Details regarding the design and construction of the device have been presented in the thesis.

Loss of mobility and independence directly affects the quality of life of many vulnerable individuals. To address this, researchers have developed wearable walking assist exoskeletons to aid users with their daily activities. While this technology has advanced tremendously in the past decade, current exoskeletons cause discomfort and injuries to the user, leading to device rejection. This research intends to develop a kinematically compatible knee joint suitable for exoskeletons. The proposed knee design can be adapted to accommodate an offset and optimize force delivery. This is achieved by ensuring that the mechanical and biological joint rotation axes are aligned and that the moment arm varies throughout flexion. Model simulations and mechanical testing of fabricated prototypes were achieved to analyze and validate the design. The results confirm the kinematic compatibility of the design and that the moment arm could be varied throughout flexion to achieve optimal and effective moment transfer.

This thesis project examined the interactive fluid dynamics between a blood pump and the univentricular Fontan circulation. 2-D particle image velocimetry (PIV) measurements were conducted on an idealized total cavopulmonary connection (TCPC) with an axial pump prototype in the inferior vena cava (IVC). Fluid velocity profiles were examined under various physiologic conditions for Fontan patients. The velocity profiles for all cases demonstrated the shunting of flow from the IVC toward the right pulmonary artery. A rotational component in the pump outflow was observed forcing flow to the periphery as compared to the flow profile without a pump present in the IVC. The inclusion of the pump provides a pressure rise of 3 to 9 mmHg. These results demonstrate the ability of the intravascular blood pump to support a Fontan circulation and support the continued optimization and development of the pump.